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Synthesis of beta-heterosubstituted alpha,alpha-disubstituted alpha-amino acid derivatives via enzyme-catalyzed desymmetrization

Research Project

Project/Area Number 24790122
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Drug development chemistry
Research InstitutionYasuda Women's University

Principal Investigator

NISHIMURA Yoshio  安田女子大学, 薬学部, 助教 (60431516)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsβ-ヘテロ置換α,α-二置換α-アミノ酸 / リパーゼ触媒 / 非対称化 / 1,3-ジオール / アジリジン / 不斉四級炭素 / β-ヘテロα,α-二置換α-アミノ酸 / 不斉四級中心 / β,β-二置換α-アミノ酸
Research Abstract

alpha,alpha-disubstituted beta-amino acids having heteroatoms (oxygen, sulfur or nitrogen) at beta-position are versatile intermediates for synthesis of drugs. In this project, we set up our goal to establish novel and efficient methods to assemble them via lipase-catalyzed enantioselective acetylation (desymmetrization) of symmetric 1,3-propanediol to construct the asymmetric quaternary carbon center.
Ranirestat, an aldose reductase inhibitor for treatment of diabetic complications, has beta-heterosubstituted alpha,alpha-disubstituted alpha-amino acid moiety, and is enantioselectively synthesized (>99% enantiomeric excess). A practical and enantioselective method to access N-carbobenzoxy (S)-alpha-methylserine is also established.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (9 results)

  • [Journal Article] Synthesis of 4,6-Unsubstituted 2-Aminodihydropyrimidine-5-Carboxylates via Sequential Staudinger/Aza-Wittig/Cyclization Reactions2015

    • Author(s)
      Y. Nishimura, H. Cho
    • Journal Title

      Synlett

      Volume: (in press) Issue: 02 Pages: 233-237

    • DOI

      10.1055/s-0034-1378932

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and Substrate Range of Streptomyces Vanillate Demethylase2014

    • Author(s)
      M. Nishimura, Y. Nishimura, C. Abe, M. Kohhata
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 37 Pages: 1564-1568

    • NAID

      130004057438

    • Related Report
      2013 Final Research Report
  • [Journal Article] Synthesis of 4-unsubstituted dihydropyrimidines having acyl and alkoxycarbonyl groups at 5-and 6-positions by cyclization-elimination reactions using 1,3-diaza-1,3-butadienes2014

    • Author(s)
      Y. Nishimura, H. Cho
    • Journal Title

      Tetrahedron Lett.

      Volume: 55 Pages: 411-414

    • Related Report
      2013 Final Research Report
  • [Journal Article] Synthesis of 4-unsubstituted dihydropyrimidines having acyl and alkoxycarbonyl groups at 5- and 6-positions by cyclization-elimination reactions using 1,3-diza-1,3-butadienes2014

    • Author(s)
      Y. Nishimura, H. Cho
    • Journal Title

      Tetrahedron Letters

      Volume: 55 Issue: 2 Pages: 411-414

    • DOI

      10.1016/j.tetlet.2013.11.038

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of novel 2-phenyl-5substituted dihydropyrimidines using 2-phenyl-1,3-diaza-1,3-butadienes and electron-deficient olefins2012

    • Author(s)
      Y. Nishimura, Y. Yasui, S. Kobayashi, M. Yamaguchi, H. Cho
    • Journal Title

      Tetrahedron

      Volume: 68 Pages: 3342-3350

    • Related Report
      2013 Final Research Report
  • [Journal Article] Synthesis of novel 2-phenyl-5-substituted dihydropyrimidines using 2-phenyl-1,3-diaza-1,3-butadienes and electron-deficient olefins2012

    • Author(s)
      Yoshio Nishimura, Yoshizumi Yasui, Satoshi Kobayashi, Masahiko Yamaguchi, Hidetsura Cho
    • Journal Title

      Tetrahedron

      Volume: 68 Issue: 16 Pages: 3342-3350

    • DOI

      10.1016/j.tet.2012.02.064

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] リパーゼによるdesymmetrizationを利用したN-Cbz (S)-α-メチルセリンの実用的合成プロセスの開発2014

    • Author(s)
      西村良夫、雲地早紀、久常由加里、岡水涼、森川瞳、西博行、生中雅也
    • Organizer
      日本プロセス化学会2014サマーシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 5,6-位にケトン、エステル基を有する4-無置換ジヒドロピリミジン誘導体の合成2014

    • Author(s)
      西村良夫、長秀連
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] 5,6-位にケトン、エステル基を有する4-無置換ジヒドロピリミジン誘導体の合成」(口頭発表2014

    • Author(s)
      西村良夫、長秀連
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 1,3-ジアザ-1,3-ブタジエンとオレフィンの環化反応を利用したジヒドロピリミジン誘導体の新しい合成法の開発2013

    • Author(s)
      西村良夫、安井義純、小林学史、山口雅彦、長秀連
    • Organizer
      第103回有機合成シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 1,3-ジアザ-1,3-ブタジエンを用いる環化反応を利用した新規2,5二置換ジヒドロピリミジン誘導体の合成2012

    • Author(s)
      西村良夫、安井義純、小林学史、山口雅彦、長秀連
    • Organizer
      第38回反応と合成の進歩シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 1,3-ジアザ-1,3-ブタジエンを用いる2,5-二置換ジヒドロピリミジンの合成2012

    • Author(s)
      西村良夫、安井義純、小林学史、山口雅彦、長秀連
    • Organizer
      第42回複素環化学討論会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Construction of dihydropyrimidine skeleton using 1,2,4-trisubstituted-1,3-diaza-1,3-b utadienes and electron-deficientolefins2012

    • Author(s)
      H. Cho, Y. Nishimura, Y. Yasui, S.Kobayashi, M. Yamaguchi
    • Organizer
      6th Spanish Portuguese Japanese Organic Chemistry Symposium (SPJ-OCS)
    • Place of Presentation
      Lisbon, Portuguese
    • Related Report
      2013 Final Research Report
  • [Presentation] CONSTRUCTION OF DIHYDROPYRIMIDINE SKELETON USING 1,2,4-TRISUBSTITUTED-1,3-DIAZA-1,3-BUTADIENES AND ELECTRON-DEFICIENT OLEFINS2012

    • Author(s)
      Cho, H., Nishimura, Y., Yasui, Y., Kobayashi, S., Yamaguchi, M.
    • Organizer
      6th Spanish Portuguese Japanese Organic Chemistry Symposium
    • Place of Presentation
      Lisbon, Portuguese
    • Related Report
      2012 Research-status Report
  • [Presentation] 1,3-ジアザ-1,3-ブタジエンを用いる環化反応を利用した新規2,5-二置換ジヒドロピリミジン誘導体の合成2012

    • Author(s)
      西村良夫、安井義純、小林学史、山口雅彦、長 秀連
    • Organizer
      第38回反応と合成の進歩シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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