Synthesis and evaluation of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents

• Project/Area Number: 24790123
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Tokushima Bunri University
• Principal Investigator: Sakakibara Norikazu 徳島文理大学, 薬学部, 講師 (10441594)
• Co-Investigator(Renkei-kenkyūsha): TSUKAMOTO Ikuko 香川大学, 医学部 薬物生体情報学講座, 客員教授 (10183477) ; IGARASHI Junsuke 香川大学, 医学部 自律機能生理学講座, 准教授 (20346638)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: コアクロル / 血管新生促進活性 / 血管新生促進剤 / ２クロル炭素環オキセタノシンＡ / 血管新生促進作用 / 構造活性相関 / 核酸類縁体 / 2クロル炭素環オキセタノシンA / COA-Cl / S1P1受容体アゴニスト

Outline of Final Research Achievements

Six novel carbocyclic oxetanocin A analogs (2-chloro-C.OXT-A; COA-Cl) with various hydroxymethylated or spiro-conjugated cyclobutane rings at the N9-position of the 2-chloropurine moiety were synthesized and evaluated using human umbilical vein endothelial cells. All prepared compounds showed good to moderate activity with angiogenic potency. Among these compounds, 100 μM cis-trans-2',3'-bis(hydroxymethyl)cyclobutyl derivative, trans-3'-hydroxymethylcyclobutyl analog, and 3',3'-bis(hydroxymethyl)cyclobutyl derivative had greater angiogenic activity, with relative tube areas of 3.43 ± 0.44, 3.32 ± 0.53, and 3.59 ± 0.83 (mean ± SD), respectively, which was comparable to COA-Cl (3.91 ± 0.78). These data may be important for further development of this class of compounds as potential tube formation agents.

Research Products

• [Journal Article] Synthesis and evaluation of novel cyclopropane nucleoside as potential tube formation agents. (2017)
  • Author(s): Sakakibara, N.; Igarashi, J.; Takata, M.; Konishi, R.; Kato, Y.; Tsukamoto, I.
  • Journal Title: Chem. Pharm. Bull. Volume: 未定
  • NAID: 130005631529
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts. (2016)
  • Author(s): Igarashi, J.; Okamoto, R.; Yamashita, T.; Hashimoto, T.; Karita, S.; Nakai, K.; Kubota, Y.; Takata, M.; Yamaguchi, F.; Tokuda, M.; Sakakibara, N.; Tsukamoto, I.; Konishi, R.; Hirano, K.
  • Journal Title: Physiological reports Volume: 4(6)
  • Peer Reviewed / Open Access
• [Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts (2016)
  • Author(s): Igarashi, J.; Okamoto, R.; Yamashita, T.; Hashimoto, T.; Karita, S.; Nakai, K.; Kubota, Y.; Takata, M.; Yamaguchi, F.; Tokuda, M.; Sakakibara, N.; Tsukamoto, I.; Konishi, R.; Hirano, K.
  • Journal Title: Physiological reports Volume: 4(6)
  • Peer Reviewed / Open Access
• [Journal Article] Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives (2015)
  • Author(s): Sakakibara, N.; Balboni, G.; Congiu, C.; Onnis, V.; Demizu, Y.; Misawa, T.; Kurihara, M.; Kato, Y.; Maruyama, T.; Okamoto, M.; Toyama, M.; Baba, M.
  • Journal Title: Antiviral Chemistry & Chemotherapy Volume: 24(2) Pages: 62-71
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Design, synthesis, and evaluation of novel 2-halogenated or aminated carbocyclic oxetanocin A analogs as potential angiogenic agents (2015)
  • Author(s): Sakakibara, N.; Igarashi, J.; Takata, M.; Konishi, R.; Suzue, N.; Kato, Y.; Maruyama, T.; Tsukamoto, I.
  • Journal Title: Heterocycles Volume: 91(9) Pages: 1823-1832
  • NAID: 40020609194
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthesis and evaluation of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents (2015)
  • Author(s): Sakakibara, N.; Igarashi, J.; Takata, M.; Demizu, Y.; Misawa, T.; Kurihara, M.; Konishi, R.; Kato, Y.; Maruyama, T.; Tsukamoto, I.
  • Journal Title: Chem. Pharm. Bull. Volume: 63(9) Pages: 701-709
  • NAID: 130005096030
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives (2015)
  • Author(s): Sakakibara, N.; Baba, M.; Okamoto, M.; Toyama, M.; Demizu, Y.; Misawa, T.; Kurihara, M.; Irie, K.; Kato, Y.; Maruyama, T.
  • Journal Title: Antiviral Chemistry & Chemotherapy Volume: 24(1) Pages: 3-18
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives. (2015)
  • Author(s): Sakakibara, N.; Baba, M.; Okamoto, M.; Yoyama, M.; Demizu, Y.; Misawa, T.; Kurihara, M.; Irie, K.; Kato, Y.; Maruyama, T.
  • Journal Title: Antiviral Chemistry & Chemotherapy Volume: 24(1) Pages: 3-18
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells (2014)
  • Author(s): Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, TakuwaY, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I.
  • Journal Title: Pharmacology Research & Perspectives Volume: 2 Issue: 5 Pages: 68-68
  • DOI: 10.1002/prp2.68
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents. (2013)
  • Author(s): Sakakibara, N.; Hamasaki, T; Baba, M.; Demizu, Y.; Kurihara, M.; Irie, K.; Iwai, M.; Asada, E.; Kato, Y.; Maruyama, T.
  • Journal Title: Bioorg. Med. Chem. Volume: 21(18) Pages: 5900-5906
  • Peer Reviewed
• [Journal Article] A New Method for Synthesis and Angiogenic Evaluation of Leteprinim Potassium and Its Novel Analogs. (2013)
  • Author(s): Sakakibara, N.; Tsukamoto, I.; Isono, Y.; Takata, M.; Konishi, R.; Kato, Y.; Maruyama, T.
  • Journal Title: Heterocycles Volume: 87(11) Pages: 2369-2384
  • NAID: 40019844853
  • Peer Reviewed
• [Journal Article] A lignan O-methyltransferase catalyzing the regioselective methylation of matairesinol in Carthamus tinctorius. (2013)
  • Author(s): Umezawa, T., Ragamustari, S.K., Nakatsubo, T., Wada, S., Li, L., Yamamura, M., Sakakibara, N., Hattori, T., Suzuki, S., and Chiang, V.L.
  • Journal Title: Plant Biotechnology Volume: 30 Pages: 97-109
  • NAID: 10031184113
  • Peer Reviewed
• [Journal Article] Delayed administration of the nucleic acid analog 2Cl-C.OXT-A attenuates brain damage and enhances functional recovery after ischemic stroke. (2013)
  • Author(s): Okabe, N.; Nakamura, E.; Himi, N.; Narita, K.; Tsukamoto, I.; Maruyama, T.; Sakakibara, N.; Nakamura, T.; Itano, T.; Miyamoto, O.
  • Journal Title: Brain Research Volume: 1506 Pages: 115-131
  • Peer Reviewed
• [Journal Article] Novel Synthesis of Carbocyclic Oxetanocin Analogs (2-Alkoxy-C.OXT-A) and Their Tube Formation Activities of Human Umbilical Vein Endothelial Cells (HUVEC). (2012)
  • Author(s): Sakakibara, N.; Tsukamoto, I.; Tsurura, T; Takata, M; Konishi, R; Maruyama, T.
  • Journal Title: Heterocycles Volume: 85(5) Pages: 1105-1116
  • NAID: 40019238576
  • Peer Reviewed
• [Journal Article] Anti-human immunodeficiency virus type 1 activity of novel 6-substituted 1-benzyl-3-(3,5-dimethylbenzyl)uracil derivatives (2012)
  • Author(s): Ordonez, P; Hamasaki, T; Isono, Y; Sakakibara, N; Ikejiri, M; Maruyama, T; Baba, M.
  • Journal Title: Antimicrob. Agents Chemother Volume: 56(5) Pages: 2581-2589
  • Peer Reviewed
• [Journal Article] First Synthesis of [6-15N]-Cladribine using Ribonucleoside as a Starting Material. (2012)
  • Author(s): Sakakibara, N.; Kakoh, A.; Maruyama, T.
  • Journal Title: Heterocycles Volume: 85(1), Pages: 171-182
  • NAID: 40019138138
  • Peer Reviewed
• [Presentation] アデノシンアナログCOA-Clの神経栄養／保護作用-(2) (2016)
  • Author(s): 塚本郁子，榊原紀和，五十嵐淳介，徳田雅明，窪田泰夫，高田麻紀，小西良士
  • Organizer: 第89回日本生化学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
• [Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA (COA-Cl)の新規2-置換型類縁体の創製研究 (2016)
  • Author(s): 榊原紀和，五十嵐淳介，高田麻紀，小西良士，鈴江奈月,加藤善久，丸山徳見，塚本郁子
  • Organizer: 日本ケミカルバイオロジー学会第11回年会
  • Place of Presentation: 京都
  • Year and Date: 2016-06-15
• [Presentation] 薬剤耐性癌細胞におけるドキソルビシン・クルクミン封入リポソームの効果に関する検討 (2016)
  • Author(s): 跡部一孝，栗田拓朗，榊原紀和，加藤善久
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-26
• [Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規2-置換型類縁体の合成とその血管新生促進作用 (2016)
  • Author(s): 榊原紀和，五十嵐淳介，高田麻紀，小西良士，鈴江奈月，加藤善久，丸山徳見，塚本郁子
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-26
• [Presentation] 新規核酸アナログCOA-Cl の神経保護栄養作用 (2016)
  • Author(s): 塚本郁子，高田麻紀，窪田泰夫，徳田雅明，榊原紀和，五十嵐淳介，小西良士
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-26
• [Presentation] 血管新生促進剤を指向した新規COA-Cl類縁体の創製研究 (2016)
  • Author(s): 榊原紀和
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-22
  • Invited
• [Presentation] 血管新生促進作用を有する新規2-クロル炭素環オキセタノシンA (COA-Cl)誘導体の創製 (2015)
  • Author(s): 榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2015-11-25
• [Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規誘導体の合成とその血管新生促進作用 (2015)
  • Author(s): 榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
  • Organizer: 第45回複素環化学討論会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-19
• [Presentation] A Key Role of PGC-1α Co-transcription Factor, but not HIF1α Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic Agent COA-Cl in Cultured Human Fibroblasts (2015)
  • Author(s): Okamoto, R., Igarashi, J., Yamashita, T., Hashimoto, T., Karita, S., Shoji, K., Kubota, Y., Takata, M., Yamaguchi, F., Tokuda, M., Sakakibara, N., Tsukamoto, I., Konishi, R., Hirano, K.
  • Organizer: The American Heart Association’s Scientific Sessions 2015
  • Place of Presentation: アメリカ・フロリダ
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA(COA-Cl)の新規誘導体の創製研究 (2015)
  • Author(s): 榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
  • Organizer: 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 高知
  • Year and Date: 2015-10-31
• [Presentation] Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives (2015)
  • Author(s): Sakakibara, N., Balboni, G., Congiu, C., Onnis, V., Demizu, Y., Misawa, T., Kurihara, M., Kato, Y., Maruyama, T., Toyama, M., Okamoto, M., Baba, M.
  • Organizer: The 42nd International Symposium on Nucleic Acids Chemistry 2015
  • Place of Presentation: 姫路
  • Year and Date: 2015-09-23
  • Int'l Joint Research
• [Presentation] 新規トリアジン誘導体の合成とそれらの抗HIV-1活性評価 (2015)
  • Author(s): 榊原紀和，Balboni, G., Congiu, C., Onnis, V., 出水庸介，三澤隆史，栗原正明，加藤善久，丸山徳見, 外山政明，岡本実佳，馬場昌範
  • Organizer: 日本ケミカルバイオロジー学会第10回年会
  • Place of Presentation: 仙台
  • Year and Date: 2015-06-10
• [Presentation] 抗HIV-1剤を指向した新規トリアジン誘導体の創製研究 (2015)
  • Author(s): 榊原紀和，馬場昌範，岡本実佳，外山政明，Balboni, G., Congiu, C., Onnis, V., 出水庸介，三澤隆史，栗原正明，加藤善久，丸山徳見
  • Organizer: 第25回抗ウイルス療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-22
• [Presentation] 3,5-ジメチルベンジル基を有するウラシル誘導体および尿素誘導体の合成とそれらの抗HIV-1活性評価 (2015)
  • Author(s): 榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，三澤隆史，栗原正明，入江晃司，加藤善久，丸山徳見
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 抗HIV-1剤を指向した1-置換型ウラシル誘導体および尿素誘導体の創製研究 (2014)
  • Author(s): 榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，三澤隆史，栗原正明，入江晃司，加藤善久，丸山徳見
  • Organizer: 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 広島
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives. (2014)
  • Author(s): Sakakibara, N., Baba, M., Okamoto, M., Toyama, M., Demizu, Y., Misawa, T., Kurihara, M., Irie, K., Kato, Y., and Maruyama, T
  • Organizer: The 41th International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: 北九州
  • Year and Date: 2014-11-05 – 2014-11-07
• [Presentation] HUVECにおけるCOA-Clの血管新生作用に対するS1Pレセプターの関与 (2014)
  • Author(s): 塚本郁子，五十嵐淳介，橋本剛，山下哲生，榊原紀和，丸山徳見，高田麻紀，窪田泰夫，平野勝也，小西良士
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 抗HIV-1剤を指向した1-置換型3-(3,5-ジメチルベンジル)ウラシルの創製研究 (2014)
  • Author(s): 榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，栗原正明，入江晃司，加藤善久，丸山徳見
  • Organizer: 第9回日本ケミカルバイオロジー学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-11 – 2014-06-13
• [Presentation] 新規3-(3,5-ジメチルベンジル)ウラシル誘導体の合成とそれらの抗HIV-1活性評価 (2014)
  • Author(s): 榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，栗原正明，入江晃司，加藤善久，丸山徳見
  • Organizer: 第24回抗ウイルス療法研究会総会
  • Place of Presentation: 山梨
  • Year and Date: 2014-05-07 – 2014-05-09
• [Presentation] Physiological activities of the rare sugar derivatives (2014)
  • Author(s): Tsukamoto, I., Takata, M., Kubota, Y., Kawanami, Y., Sakakibara, N., Maruyama, T., Tokuda, M., and Konishi, R.
  • Organizer: Rare Sugar Symposium 2014 in Kagawa
  • Place of Presentation: 高松
  • Year and Date: 2014-04-29 – 2014-04-30
• [Presentation] 3-(3,5-ジメチルベンジル)ウラシルの新規誘導体の合成とそれらの抗HIV-1活性 (2013)
  • Author(s): 榊原紀和, 濱崎隆之, 馬場昌範, 出水庸介，栗原正明，入江晃司, 岩井雅俊, 加藤善久, 丸山徳見
  • Organizer: 第23回抗ウイルス療法研究会総会
  • Place of Presentation: 東京
• [Presentation] A newly synthesized adenosine analogue, COA-Cl has angiogenic potency (2013)
  • Author(s): Tsukamoto, I., Takata, M., Sakakibara, N., Maruyama, T., Igarashi, J., Kosaka, H., Kubota, Y., Tokuda, M., Ashino, H., Hattori, K., Tanaka, S., Kawata, M., and Konishi, R.
  • Organizer: International Pharmaceutical Federation
  • Place of Presentation: Dublin, Ireland.
• [Presentation] アデノシンアナログCOA-Clの神経栄養／保護作用 (2013)
  • Author(s): 塚本郁子，榊原紀和，丸山徳見，五十嵐淳介，小坂博昭，徳田雅明，窪田泰夫，高田麻紀，小西良士
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] 簡便な3-(3,5-ジメチルベンジル)ウラシルの新規誘導体の合成とその抗HIV-1活性評価 (2013)
  • Author(s): 榊原紀和，濱崎隆之，馬場昌範，出水庸介，栗原正明，入江晃司, 岩井雅俊，加藤善久, 丸山徳見
  • Organizer: 第43回複素環化学討論会
  • Place of Presentation: 岐阜
• [Presentation] 血管新生促進作用および抗がん作用を有する新規核酸類縁体その創製 (2013)
  • Author(s): 榊原紀和
  • Organizer: 第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 松山
  • Invited
• [Presentation] 非核酸系逆転写酵素阻害剤としての新規ウラシル誘導体合成とその抗HIV-1活性評価 (2013)
  • Author(s): 榊原紀和，濱崎隆之，馬場昌範，出水庸介，栗原正明，入江晃司, 岩井雅俊，加藤善久, 丸山徳見
  • Organizer: 第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 松山
• [Presentation] Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)- uracil analogs as potential anti-HIV-1 agents. (2013)
  • Author(s): Sakakibara, N., Hamasaki, T., Baba, M., Demizu, Y., Kurihara, M., Irie, K., Iwai, M., Kato, Y., and Maruyama, T.
  • Organizer: The 40th International Symposium on Nucleic Acids Chemistry 2013
  • Place of Presentation: Yokohama, Japan.
• [Presentation] 6位にアミン類を導入した1-ベンジル-3-(3,5-ジメチルベンジル)ウラシル誘導体の合成とそれらの抗HIV-1活性 (2013)
  • Author(s): 榊原紀和，濱崎隆之，馬場昌範，岩井雅俊，加藤善久, 丸山徳見
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] 6-アジド-及び6-アミノ-3-(3,5-ジメチルベンジル)ウラシルの新規1-置換誘導体の合成とそれらの抗HIV-1活性 (2013)
  • Author(s): 榊原紀和，濱崎隆之，馬場昌範，入江晃司，加藤善久, 丸山徳見
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] Synthesis of 1-benzyl-3- (3,5-dimethylbenzyl)uracil derivatives with potential anti-HIV activity (2012)
  • Author(s): Yohei Isono, Norikazu Sakakibara, Paula Ordonez, Takayuki Hamasaki, Masanori Baba, Masahiro Ikejiri, and Tokumi Maruyama
  • Organizer: The 25th International Conference on Antiviral Research
  • Place of Presentation: 札幌
• [Presentation] 新規開発した方法による2-アルコキシ-C.OXT-Aの合成と血管新生促進活性評価 (2012)
  • Author(s): 榊原紀和，塚本郁子，鶴田崇，丸山徳見
  • Organizer: 日本薬剤学会第27年会
  • Place of Presentation: 神戸
• [Presentation] Synthesis of carbocyclic oxetanocin analogs (2-alkoxy- C.OXT-A) and their tube formation activities of human umbilical vein endothelial cells (HUVEC) (2012)
  • Author(s): Norikazu Sakakibara, Ikuko Tsukamoto, Takashi Tsuruta, Maki Takata, Ryoji Konishi, and Tokumi Maruyama
  • Organizer: The 6th Takeda Science Foundation Symposium on PharmaSciences
  • Place of Presentation: 大阪
• [Remarks] 徳島文理大学香川薬学部薬物動態学講座 研究業績
  • URL: http://kp.bunri-u.ac.jp/kph17/gyouseki/index.html
• [Remarks] 徳島文理大学 各教員の業績及び保有学位（５０音順）
  • URL: http://www.bunri-u.ac.jp/about/edu-info/pdf/teacher/1060018.pdf#search=%27%E6%A6%8A%E5%8E%9F%E7%B4%80%E5%92%8C%27
• [Remarks] 徳島文理大学香川薬学部のホームページ上の「榊原紀和の研究業績」
  • URL: http://kp.bunri-u.ac.jp/kph17/gyouseki/index.html
• [Remarks] 徳島文理大学香川薬学部のホームページ上の「榊原紀和の主要な研究テーマ」
  • URL: http://kp.bunri-u.ac.jp/kph17/kyouin/index.html
• [Remarks] 徳島文理大学香川薬学部薬物動態学講座のホームページ中の「榊原紀和の現在の主要研究テーマ」
  • URL: http://kp.bunri-u.ac.jp/kph17/kyouin/index.html
• [Remarks] 徳島文理大学香川薬学部薬物動態学講座のホームページ中の「研究業績」
  • URL: http://kp.bunri-u.ac.jp/kph17/gyouseki/index.html