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Synthesis and evaluation of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents

Research Project

Project/Area Number 24790123
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Drug development chemistry
Research InstitutionTokushima Bunri University

Principal Investigator

Sakakibara Norikazu  徳島文理大学, 薬学部, 講師 (10441594)

Co-Investigator(Renkei-kenkyūsha) TSUKAMOTO Ikuko  香川大学, 医学部 薬物生体情報学講座, 客員教授 (10183477)
IGARASHI Junsuke  香川大学, 医学部 自律機能生理学講座, 准教授 (20346638)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsコアクロル / 血管新生促進活性 / 血管新生促進剤 / 2クロル炭素環オキセタノシンA / 血管新生促進作用 / 構造活性相関 / 核酸類縁体 / 2クロル炭素環オキセタノシンA / COA-Cl / S1P1受容体アゴニスト
Outline of Final Research Achievements

Six novel carbocyclic oxetanocin A analogs (2-chloro-C.OXT-A; COA-Cl) with various hydroxymethylated or spiro-conjugated cyclobutane rings at the N9-position of the 2-chloropurine moiety were synthesized and evaluated using human umbilical vein endothelial cells. All prepared compounds showed good to moderate activity with angiogenic potency. Among these compounds, 100 μM cis-trans-2',3'-bis(hydroxymethyl)cyclobutyl derivative, trans-3'-hydroxymethylcyclobutyl analog, and 3',3'-bis(hydroxymethyl)cyclobutyl derivative had greater angiogenic activity, with relative tube areas of 3.43 ± 0.44, 3.32 ± 0.53, and 3.59 ± 0.83 (mean ± SD), respectively, which was comparable to COA-Cl (3.91 ± 0.78). These data may be important for further development of this class of compounds as potential tube formation agents.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (54 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Acknowledgement Compliant: 6 results,  Open Access: 4 results) Presentation (32 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (6 results)

  • [Journal Article] Synthesis and evaluation of novel cyclopropane nucleoside as potential tube formation agents.2017

    • Author(s)
      Sakakibara, N.; Igarashi, J.; Takata, M.; Konishi, R.; Kato, Y.; Tsukamoto, I.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 未定

    • NAID

      130005631529

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts.2016

    • Author(s)
      Igarashi, J.; Okamoto, R.; Yamashita, T.; Hashimoto, T.; Karita, S.; Nakai, K.; Kubota, Y.; Takata, M.; Yamaguchi, F.; Tokuda, M.; Sakakibara, N.; Tsukamoto, I.; Konishi, R.; Hirano, K.
    • Journal Title

      Physiological reports

      Volume: 4(6)

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts2016

    • Author(s)
      Igarashi, J.; Okamoto, R.; Yamashita, T.; Hashimoto, T.; Karita, S.; Nakai, K.; Kubota, Y.; Takata, M.; Yamaguchi, F.; Tokuda, M.; Sakakibara, N.; Tsukamoto, I.; Konishi, R.; Hirano, K.
    • Journal Title

      Physiological reports

      Volume: 4(6)

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives2015

    • Author(s)
      Sakakibara, N.; Balboni, G.; Congiu, C.; Onnis, V.; Demizu, Y.; Misawa, T.; Kurihara, M.; Kato, Y.; Maruyama, T.; Okamoto, M.; Toyama, M.; Baba, M.
    • Journal Title

      Antiviral Chemistry & Chemotherapy

      Volume: 24(2) Pages: 62-71

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Design, synthesis, and evaluation of novel 2-halogenated or aminated carbocyclic oxetanocin A analogs as potential angiogenic agents2015

    • Author(s)
      Sakakibara, N.; Igarashi, J.; Takata, M.; Konishi, R.; Suzue, N.; Kato, Y.; Maruyama, T.; Tsukamoto, I.
    • Journal Title

      Heterocycles

      Volume: 91(9) Pages: 1823-1832

    • NAID

      40020609194

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis and evaluation of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents2015

    • Author(s)
      Sakakibara, N.; Igarashi, J.; Takata, M.; Demizu, Y.; Misawa, T.; Kurihara, M.; Konishi, R.; Kato, Y.; Maruyama, T.; Tsukamoto, I.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 63(9) Pages: 701-709

    • NAID

      130005096030

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives2015

    • Author(s)
      Sakakibara, N.; Baba, M.; Okamoto, M.; Toyama, M.; Demizu, Y.; Misawa, T.; Kurihara, M.; Irie, K.; Kato, Y.; Maruyama, T.
    • Journal Title

      Antiviral Chemistry & Chemotherapy

      Volume: 24(1) Pages: 3-18

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives.2015

    • Author(s)
      Sakakibara, N.; Baba, M.; Okamoto, M.; Yoyama, M.; Demizu, Y.; Misawa, T.; Kurihara, M.; Irie, K.; Kato, Y.; Maruyama, T.
    • Journal Title

      Antiviral Chemistry & Chemotherapy

      Volume: 24(1) Pages: 3-18

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells2014

    • Author(s)
      Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, TakuwaY, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I.
    • Journal Title

      Pharmacology Research & Perspectives

      Volume: 2 Issue: 5 Pages: 68-68

    • DOI

      10.1002/prp2.68

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents.2013

    • Author(s)
      Sakakibara, N.; Hamasaki, T; Baba, M.; Demizu, Y.; Kurihara, M.; Irie, K.; Iwai, M.; Asada, E.; Kato, Y.; Maruyama, T.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 21(18) Pages: 5900-5906

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A New Method for Synthesis and Angiogenic Evaluation of Leteprinim Potassium and Its Novel Analogs.2013

    • Author(s)
      Sakakibara, N.; Tsukamoto, I.; Isono, Y.; Takata, M.; Konishi, R.; Kato, Y.; Maruyama, T.
    • Journal Title

      Heterocycles

      Volume: 87(11) Pages: 2369-2384

    • NAID

      40019844853

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A lignan O-methyltransferase catalyzing the regioselective methylation of matairesinol in Carthamus tinctorius.2013

    • Author(s)
      Umezawa, T., Ragamustari, S.K., Nakatsubo, T., Wada, S., Li, L., Yamamura, M., Sakakibara, N., Hattori, T., Suzuki, S., and Chiang, V.L.
    • Journal Title

      Plant Biotechnology

      Volume: 30 Pages: 97-109

    • NAID

      10031184113

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Delayed administration of the nucleic acid analog 2Cl-C.OXT-A attenuates brain damage and enhances functional recovery after ischemic stroke.2013

    • Author(s)
      Okabe, N.; Nakamura, E.; Himi, N.; Narita, K.; Tsukamoto, I.; Maruyama, T.; Sakakibara, N.; Nakamura, T.; Itano, T.; Miyamoto, O.
    • Journal Title

      Brain Research

      Volume: 1506 Pages: 115-131

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel Synthesis of Carbocyclic Oxetanocin Analogs (2-Alkoxy-C.OXT-A) and Their Tube Formation Activities of Human Umbilical Vein Endothelial Cells (HUVEC).2012

    • Author(s)
      Sakakibara, N.; Tsukamoto, I.; Tsurura, T; Takata, M; Konishi, R; Maruyama, T.
    • Journal Title

      Heterocycles

      Volume: 85(5) Pages: 1105-1116

    • NAID

      40019238576

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-human immunodeficiency virus type 1 activity of novel 6-substituted 1-benzyl-3-(3,5-dimethylbenzyl)uracil derivatives2012

    • Author(s)
      Ordonez, P; Hamasaki, T; Isono, Y; Sakakibara, N; Ikejiri, M; Maruyama, T; Baba, M.
    • Journal Title

      Antimicrob. Agents Chemother

      Volume: 56(5) Pages: 2581-2589

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] First Synthesis of [6-15N]-Cladribine using Ribonucleoside as a Starting Material.2012

    • Author(s)
      Sakakibara, N.; Kakoh, A.; Maruyama, T.
    • Journal Title

      Heterocycles

      Volume: 85(1), Pages: 171-182

    • NAID

      40019138138

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] アデノシンアナログCOA-Clの神経栄養/保護作用-(2)2016

    • Author(s)
      塚本郁子,榊原紀和,五十嵐淳介,徳田雅明,窪田泰夫,高田麻紀,小西良士
    • Organizer
      第89回日本生化学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA (COA-Cl)の新規2-置換型類縁体の創製研究2016

    • Author(s)
      榊原紀和,五十嵐淳介,高田麻紀,小西良士,鈴江奈月,加藤善久,丸山徳見,塚本郁子
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 薬剤耐性癌細胞におけるドキソルビシン・クルクミン封入リポソームの効果に関する検討2016

    • Author(s)
      跡部一孝,栗田拓朗,榊原紀和,加藤善久
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規2-置換型類縁体の合成とその血管新生促進作用2016

    • Author(s)
      榊原紀和,五十嵐淳介,高田麻紀,小西良士,鈴江奈月,加藤善久,丸山徳見,塚本郁子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規核酸アナログCOA-Cl の神経保護栄養作用2016

    • Author(s)
      塚本郁子,高田麻紀,窪田泰夫,徳田雅明,榊原紀和,五十嵐淳介,小西良士
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 血管新生促進剤を指向した新規COA-Cl類縁体の創製研究2016

    • Author(s)
      榊原紀和
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 血管新生促進作用を有する新規2-クロル炭素環オキセタノシンA (COA-Cl)誘導体の創製2015

    • Author(s)
      榊原紀和,五十嵐淳介,高田麻紀,出水庸介,三澤隆史,栗原正明,小西良士,加藤善久,丸山徳見,塚本郁子
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
  • [Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規誘導体の合成とその血管新生促進作用2015

    • Author(s)
      榊原紀和,五十嵐淳介,高田麻紀,出水庸介,三澤隆史,栗原正明,小西良士,加藤善久,丸山徳見,塚本郁子
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] A Key Role of PGC-1α Co-transcription Factor, but not HIF1α Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic Agent COA-Cl in Cultured Human Fibroblasts2015

    • Author(s)
      Okamoto, R., Igarashi, J., Yamashita, T., Hashimoto, T., Karita, S., Shoji, K., Kubota, Y., Takata, M., Yamaguchi, F., Tokuda, M., Sakakibara, N., Tsukamoto, I., Konishi, R., Hirano, K.
    • Organizer
      The American Heart Association’s Scientific Sessions 2015
    • Place of Presentation
      アメリカ・フロリダ
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA(COA-Cl)の新規誘導体の創製研究2015

    • Author(s)
      榊原紀和,五十嵐淳介,高田麻紀,出水庸介,三澤隆史,栗原正明,小西良士,加藤善久,丸山徳見,塚本郁子
    • Organizer
      第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高知
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives2015

    • Author(s)
      Sakakibara, N., Balboni, G., Congiu, C., Onnis, V., Demizu, Y., Misawa, T., Kurihara, M., Kato, Y., Maruyama, T., Toyama, M., Okamoto, M., Baba, M.
    • Organizer
      The 42nd International Symposium on Nucleic Acids Chemistry 2015
    • Place of Presentation
      姫路
    • Year and Date
      2015-09-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新規トリアジン誘導体の合成とそれらの抗HIV-1活性評価2015

    • Author(s)
      榊原紀和,Balboni, G., Congiu, C., Onnis, V., 出水庸介,三澤隆史,栗原正明,加藤善久,丸山徳見, 外山政明,岡本実佳,馬場昌範
    • Organizer
      日本ケミカルバイオロジー学会第10回年会
    • Place of Presentation
      仙台
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 抗HIV-1剤を指向した新規トリアジン誘導体の創製研究2015

    • Author(s)
      榊原紀和,馬場昌範,岡本実佳,外山政明,Balboni, G., Congiu, C., Onnis, V., 出水庸介,三澤隆史,栗原正明,加藤善久,丸山徳見
    • Organizer
      第25回抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 3,5-ジメチルベンジル基を有するウラシル誘導体および尿素誘導体の合成とそれらの抗HIV-1活性評価2015

    • Author(s)
      榊原紀和,馬場昌範,岡本実佳,外山政明,出水庸介,三澤隆史,栗原正明,入江晃司,加藤善久,丸山徳見
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗HIV-1剤を指向した1-置換型ウラシル誘導体および尿素誘導体の創製研究2014

    • Author(s)
      榊原紀和,馬場昌範,岡本実佳,外山政明,出水庸介,三澤隆史,栗原正明,入江晃司,加藤善久,丸山徳見
    • Organizer
      第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      広島
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives.2014

    • Author(s)
      Sakakibara, N., Baba, M., Okamoto, M., Toyama, M., Demizu, Y., Misawa, T., Kurihara, M., Irie, K., Kato, Y., and Maruyama, T
    • Organizer
      The 41th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      北九州
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] HUVECにおけるCOA-Clの血管新生作用に対するS1Pレセプターの関与2014

    • Author(s)
      塚本郁子,五十嵐淳介,橋本剛,山下哲生,榊原紀和,丸山徳見,高田麻紀,窪田泰夫,平野勝也,小西良士
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗HIV-1剤を指向した1-置換型3-(3,5-ジメチルベンジル)ウラシルの創製研究2014

    • Author(s)
      榊原紀和,馬場昌範,岡本実佳,外山政明,出水庸介,栗原正明,入江晃司,加藤善久,丸山徳見
    • Organizer
      第9回日本ケミカルバイオロジー学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 新規3-(3,5-ジメチルベンジル)ウラシル誘導体の合成とそれらの抗HIV-1活性評価2014

    • Author(s)
      榊原紀和,馬場昌範,岡本実佳,外山政明,出水庸介,栗原正明,入江晃司,加藤善久,丸山徳見
    • Organizer
      第24回抗ウイルス療法研究会総会
    • Place of Presentation
      山梨
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Physiological activities of the rare sugar derivatives2014

    • Author(s)
      Tsukamoto, I., Takata, M., Kubota, Y., Kawanami, Y., Sakakibara, N., Maruyama, T., Tokuda, M., and Konishi, R.
    • Organizer
      Rare Sugar Symposium 2014 in Kagawa
    • Place of Presentation
      高松
    • Year and Date
      2014-04-29 – 2014-04-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 3-(3,5-ジメチルベンジル)ウラシルの新規誘導体の合成とそれらの抗HIV-1活性2013

    • Author(s)
      榊原紀和, 濱崎隆之, 馬場昌範, 出水庸介,栗原正明,入江晃司, 岩井雅俊, 加藤善久, 丸山徳見
    • Organizer
      第23回抗ウイルス療法研究会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] A newly synthesized adenosine analogue, COA-Cl has angiogenic potency2013

    • Author(s)
      Tsukamoto, I., Takata, M., Sakakibara, N., Maruyama, T., Igarashi, J., Kosaka, H., Kubota, Y., Tokuda, M., Ashino, H., Hattori, K., Tanaka, S., Kawata, M., and Konishi, R.
    • Organizer
      International Pharmaceutical Federation
    • Place of Presentation
      Dublin, Ireland.
    • Related Report
      2013 Research-status Report
  • [Presentation] アデノシンアナログCOA-Clの神経栄養/保護作用2013

    • Author(s)
      塚本郁子,榊原紀和,丸山徳見,五十嵐淳介,小坂博昭,徳田雅明,窪田泰夫,高田麻紀,小西良士
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 簡便な3-(3,5-ジメチルベンジル)ウラシルの新規誘導体の合成とその抗HIV-1活性評価2013

    • Author(s)
      榊原紀和,濱崎隆之,馬場昌範,出水庸介,栗原正明,入江晃司, 岩井雅俊,加藤善久, 丸山徳見
    • Organizer
      第43回複素環化学討論会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Research-status Report
  • [Presentation] 血管新生促進作用および抗がん作用を有する新規核酸類縁体その創製2013

    • Author(s)
      榊原紀和
    • Organizer
      第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      松山
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 非核酸系逆転写酵素阻害剤としての新規ウラシル誘導体合成とその抗HIV-1活性評価2013

    • Author(s)
      榊原紀和,濱崎隆之,馬場昌範,出水庸介,栗原正明,入江晃司, 岩井雅俊,加藤善久, 丸山徳見
    • Organizer
      第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      松山
    • Related Report
      2013 Research-status Report
  • [Presentation] Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)- uracil analogs as potential anti-HIV-1 agents.2013

    • Author(s)
      Sakakibara, N., Hamasaki, T., Baba, M., Demizu, Y., Kurihara, M., Irie, K., Iwai, M., Kato, Y., and Maruyama, T.
    • Organizer
      The 40th International Symposium on Nucleic Acids Chemistry 2013
    • Place of Presentation
      Yokohama, Japan.
    • Related Report
      2013 Research-status Report
  • [Presentation] 6位にアミン類を導入した1-ベンジル-3-(3,5-ジメチルベンジル)ウラシル誘導体の合成とそれらの抗HIV-1活性2013

    • Author(s)
      榊原紀和,濱崎隆之,馬場昌範,岩井雅俊,加藤善久, 丸山徳見
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 6-アジド-及び6-アミノ-3-(3,5-ジメチルベンジル)ウラシルの新規1-置換誘導体の合成とそれらの抗HIV-1活性2013

    • Author(s)
      榊原紀和,濱崎隆之,馬場昌範,入江晃司,加藤善久, 丸山徳見
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Synthesis of 1-benzyl-3- (3,5-dimethylbenzyl)uracil derivatives with potential anti-HIV activity2012

    • Author(s)
      Yohei Isono, Norikazu Sakakibara, Paula Ordonez, Takayuki Hamasaki, Masanori Baba, Masahiro Ikejiri, and Tokumi Maruyama
    • Organizer
      The 25th International Conference on Antiviral Research
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 新規開発した方法による2-アルコキシ-C.OXT-Aの合成と血管新生促進活性評価2012

    • Author(s)
      榊原紀和,塚本郁子,鶴田崇,丸山徳見
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Synthesis of carbocyclic oxetanocin analogs (2-alkoxy- C.OXT-A) and their tube formation activities of human umbilical vein endothelial cells (HUVEC)2012

    • Author(s)
      Norikazu Sakakibara, Ikuko Tsukamoto, Takashi Tsuruta, Maki Takata, Ryoji Konishi, and Tokumi Maruyama
    • Organizer
      The 6th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Remarks] 徳島文理大学香川薬学部薬物動態学講座 研究業績

    • URL

      http://kp.bunri-u.ac.jp/kph17/gyouseki/index.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 徳島文理大学 各教員の業績及び保有学位(50音順)

    • URL

      http://www.bunri-u.ac.jp/about/edu-info/pdf/teacher/1060018.pdf#search=%27%E6%A6%8A%E5%8E%9F%E7%B4%80%E5%92%8C%27

    • Related Report
      2014 Research-status Report
  • [Remarks] 徳島文理大学香川薬学部のホームページ上の「榊原紀和の研究業績」

    • URL

      http://kp.bunri-u.ac.jp/kph17/gyouseki/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 徳島文理大学香川薬学部のホームページ上の「榊原紀和の主要な研究テーマ」

    • URL

      http://kp.bunri-u.ac.jp/kph17/kyouin/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 徳島文理大学香川薬学部薬物動態学講座のホームページ中の「榊原紀和の現在の主要研究テーマ」

    • URL

      http://kp.bunri-u.ac.jp/kph17/kyouin/index.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 徳島文理大学香川薬学部薬物動態学講座のホームページ中の「研究業績」

    • URL

      http://kp.bunri-u.ac.jp/kph17/gyouseki/index.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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