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Development of quality evaluation method of licorice by metabolomics

Research Project

Project/Area Number 24790125
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental pharmacy
Research InstitutionOsaka University

Principal Investigator

HARADA Kazuo  大阪大学, 薬学研究科(研究院), 助教 (50397741)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords薬用資源学 / メタボローム / カンゾウ / 生薬 / 甘草 / 品質評価
Research Abstract

Quality evaluation and control of herbal medicines are important but difficult issues. Licorice is the one of the most important herb in Japan, and regulated by glycyrrhizine content according to Pharmacopeia of Japan. However, biological activities of licorice extracts, such as suppression of nitric oxide generation in macrophase cell, could not be estimated by just only glycyrrhizine content of licorice. However, those could be estimated by metabolome data which possesses comprehensive component data accurately. We suggested that metabolome data in harbal extract is quite useful for quality evaluation of herbal medicines.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2013 2012

All Journal Article (2 results) Presentation (7 results)

  • [Journal Article] カンゾウの品質評価に向けたメタボローム解析の活用2013

    • Author(s)
      原田和生,小田知佳,角明香里,高上馬希重,山本豊,Shu ZHU,小松かつ子,平田收正
    • Journal Title

      甘草研究最前線

      Pages: 71-72

    • Related Report
      2013 Final Research Report
  • [Journal Article] カンゾウの品質評価に向けたメタボローム解析の活用2013

    • Author(s)
      原田和生,小田知佳,角明香里,高上馬希重,山本豊,Shu ZHU,小松かつ子,平田收正
    • Journal Title

      甘草研究最前線2013

      Volume: 1 Pages: 71-72

    • Related Report
      2013 Annual Research Report
  • [Presentation] カンゾウの品質評価・管理に向けたメタボローム解析の活用2013

    • Author(s)
      原田和生,小田知佳,角明香里,高上馬希重,山本豊,Shu ZHU,小松かつ子,平田收正
    • Organizer
      第6回甘草に関するシンポジウム
    • Place of Presentation
      北海道医療大学
    • Year and Date
      2013-07-06
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] カンゾウの品質評価に向けたメタボローム解析の活用2013

    • Author(s)
      原田和生,小田知佳,角明香里,高上馬希重,山本豊,Shu ZHU,小松かつ子,平田收正
    • Organizer
      第8回メタボロームシンポジウム
    • Place of Presentation
      九州大学
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] カンゾウの品質評価に向けたメタボローム解析の活用2013

    • Author(s)
      原田和生,小田知佳,角明香里,高上馬希重,山本豊, Shu ZHU,小松かつ子,平田收正
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      北海道医療大学
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] カンゾウの品質評価に向けたメタボローム解析の活用2013

    • Author(s)
      原田和生,小田知佳,角明香里,高上馬希重,山本豊,Shu ZHU,小松かつ子,平田收正
    • Organizer
      第6回甘草に関するシンポジウム
    • Place of Presentation
      北海道医療大学 当別キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] カンゾウエキスの薬効評価のためのメタボローム解析の活用2012

    • Author(s)
      小田知佳,原田和生,Shu ZHU,山本豊,小松かつ子,平田收正
    • Organizer
      第62回日本薬学会近畿支部大会
    • Place of Presentation
      武庫川女子大学浜甲子園キャンパス
    • Year and Date
      2012-10-12
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] カンゾウエキスの薬効評価のためのメタボローム解析の活用2012

    • Author(s)
      小田知佳,原田和生,平田收正,Shu ZHU,小松かつ子,山本豊
    • Organizer
      日本生薬学会第59回年会
    • Place of Presentation
      かずさアカデミアパーク
    • Related Report
      2013 Final Research Report
  • [Presentation] カンゾウエキスの薬効評価のためのメタボローム解析の活用2012

    • Author(s)
      小田知佳,原田和生,平田收正,Shu ZHU,小松かつ子,山本豊
    • Organizer
      日本生薬学会 第59回年会
    • Place of Presentation
      かずさアカデミアパーク
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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