The effect and underlying epigenetic mechanism of maternal exposure to carbon nanoparticle on the immune system
| Project/Area Number |
24790130
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ナノ粒子 / 妊娠期曝露 / カーボンブラック / 脾臓 / リスク・コミュニケーション / 胸腺リンパ球 / リンパ球分化 / 転写因子 / マイクロアレイ |
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| Research Abstract |
This project aimed to clarify the effect of maternal exposure to carbon black nanoparticle on the immune system of offspring and underlying epigenetic and other mechanisms. The results indicated that epigenetics does not, but thymis transcription factors NF1 and GFI1 may contribute to the developmental effect on the immune system. In addition, exposure to carbon black nanoparticle during the period of organogenesis, the middle fetal development, may mostly contribute to its effects on the immune system of offspring mice.
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Report
(3 results)
Research Products
(95 results)
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[Presentation] Effect of treatment of pregnant mice with carbon black nanoparticle on the neonatal immune system2013
Author(s)
Okamoto S, Umezawa M, Shimizu R, Onoda A, Uchiyama M, Watanabe S, Ogawa S, Abe R, Takeda K
Organizer
6th International Symposium on Nanotechnology, Occupational and Environmental Health
Place of Presentation
Nagoya, Japan
Related Report
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[Presentation] Fetal exposure to carbon nanoparticle altered development of the neonatal immune system2012
Author(s)
Shimizu R, Umezawa M, Uchiyama M, Okamoto S, Niki R, Ogawa S, Watanabe S, Abe R, Takeda K
Organizer
PPTOXIII–the 3rd International Conference on Prenatal Programming and Toxicity, Society of Toxicology (Paris, France)
Place of Presentation
Shimizu
Related Report
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