Production and biological effects of ABAQ produced from the Maillard reaction and its relative substances in diabetes
| Project/Area Number |
24790132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 栄養化学 / 糖尿病 / 食品 / がん / 遺伝毒性 / メイラード反応 / ヘテロサイクリックアミン / 糖 / アミノ酸 / ABAQ / 血糖 |
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| Outline of Final Research Achievements |
A novel mutagen ABAQ was detected in urine collected from type 1 diabetic model rats, type 2 diabetic model rats, and normal rats. ABAQ was detected from spot urine collected from healthy persons. ABAQ was detected from foods. A mutagens excepting ABAQ was isolated from reaction mixture of glucose, L-tryptophan, and the Fenton reagent.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] In vivo genotoxicity of a novel heterocyclic amine,aminobenzoazepinoquinolinone-derivative (ABAQ), produced by theMaillard reaction between glucose and l-tryptophan2014
Author(s)
Yukari Totsuka, Tetsushi Watanabe, Souleymane Coulibaly, Sae Kobayashi, Marina Nishizaki, Miho Okazaki, Tomohiro Hasei, Keiji Wakabayashi, Hitoshi Nakagama
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Journal Title
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume: 760
Pages: 48-55
DOI
Related Report
Peer Reviewed
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