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The association between dietary supplementation during pregnancy and conditions of pregnancy, infant growth, and development of diseases among mothers and children

Research Project

Project/Area Number 24790141
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionTohoku University

Principal Investigator

OBARA Taku  東北大学, 東北メディカル・メガバンク機構, 講師 (80612019)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords妊娠 / サプリメント / 小児 / コホート / 葉酸
Outline of Final Research Achievements

The objective of this study was to clarify the association between dietary supplementation during pregnancy and conditions of pregnancy, infant growth, and development of diseases among mothers and children. Participants in the JECS additional study and those who participated in the BOSHI study was most frequently used folic acid supplement during pregnancy (20.2-35.4%), followed by mineral and vitamin B. We established the research infrastructure to clarify the association between dietary supplementation during pregnancy and conditions of pregnancy, infant growth, and development of diseases among mothers and children.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (23 results)

All 2015 2014 2013 2012

All Journal Article (14 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] Awareness regarding clinical application of pharmacogenetics among Japanese pharmacists.2015

    • Author(s)
      Obara T, Abe S, Sato M, Sergio Ramón Gutiérrez Ubeda, Yoshimachi S, Goto T.
    • Journal Title

      Pharmacogenomics and Personalized Medicine

      Volume: 8 Pages: 35-41

    • DOI

      10.2147/pgpm.s71813

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Awareness of the Japanese society of hypertension guidelines for the management of hypertension and their use in clinical practices: 2009 survey results2015

    • Author(s)
      Obara T, Sergio Ramón Gutiérrez Ubeda, Ohkubo T, MatsuuraH, Ishimitsu T, Takata T, Rakugi H, Imai Y; On behalf of Japanese Society of Hypertension recurrently education committee.
    • Journal Title

      Hypertension Research

      Volume: 38 Issue: 6 Pages: 400

    • DOI

      10.1038/hr.2015.21

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 妊婦における葉酸サプリメント摂取の評価:BOSHI研究2013

    • Author(s)
      小林由香、小原拓、目時弘仁、岩崎雅弘、佐藤博、村井ユリ子、眞野成康、鈴木雅洲、今井潤、BOSHI研究グループ
    • Journal Title

      医薬品相互作用研究

      Volume: 37 Pages: 37-42

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 東日本大震災後に薬品情報室に寄せられた問い合わせに関する調査2013

    • Author(s)
      吉中千佳、尾崎芙実、小原拓、草場美津江、前川麻央、松浦正樹、佐賀利英、中村浩規、久道周彦、佐藤真由美、我妻恭行、眞野成康
    • Journal Title

      日本病院薬剤師会雑誌

      Volume: 49 Pages: 877-881

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 後発医薬品に対する薬剤師の認識:社団法人仙台市薬剤師会2013

    • Author(s)
      高橋則男、小原拓、猪狩有紀恵、高橋武、東二丁裕子、遠藤孝、眞野成康、早坂正孝、高橋將喜、鎌田裕、北村哲治
    • Journal Title

      医薬品相互作用研究

      Volume: 36 Pages: 168-172

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Logistic regression analysis of risk factors for prolonged pulmonary recovery in children from aspirated foreign body.2013

    • Author(s)
      Hidaka H, Obara T, Kuriyama S, Kurosawa S, Katori Y, Kobayashi T.
    • Journal Title

      Int J Pediatr Otorhinolaryngol.

      Volume: 77 Pages: 1677-1682

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The reason why home blood pressure measurements are preferred over clinic or ambulatory blood pressure in Japan.2013

    • Author(s)
      Imai Y, Obara T, Asamaya K, Ohkubo T.
    • Journal Title

      Hypertens Res

      Volume: 36 Pages: 661-672

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Change of the Management of Treated Hypertensive Patients with or without Diabetes in Japan. Clin Exp Hypertens2013

    • Author(s)
      Obara T, Ohkubo T, Ishikura K, Shibamiya T, Ikeda U, Metoki H, Kikuya M, Mano N, Kuriyama S, Imai Y; the J-HOME study group, the J-HOME-Morning study group
    • Journal Title

      Clin Exp Hypertens

      Volume: 35 Pages: 79-86

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Compliance to the recommendations on blood pressure measurements in the clinical settings2013

    • Author(s)
      Obara T, Ohkubo T, Mano N, Kuriyama S, Imai Y
    • Journal Title

      J Hypertens

      Volume: 31 Pages: 213-213

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associations Between Visit-to-visit Variability in Blood Pressure Measured in the Office and Antihypertensive Drugs: The J-HOME-Morning Study2013

    • Author(s)
      Obara T, Kikuya M, Kobayashi Y, Ishikura K, Ikeda U, Ishikuro M, Metoki H, Mano N, Kuriyama S, Ohkubo T, Imai Y, The J-Home-Morning Study Group
    • Journal Title

      Clin Exp Hypertens

      Volume: 35

    • Related Report
      2012 Research-status Report
  • [Journal Article] 葉酸の神経管閉鎖障害リスク低下効果に関する薬剤師の認識2012

    • Author(s)
      小原拓, 村井ユリ子, 猪狩有紀恵, 原梓, 岸川幸生, 早坂正孝, 鎌田裕, 眞野成康, 高橋將喜, 生出泉太郎, 北村哲治
    • Journal Title

      医薬品情報学

      Volume: 13 Pages: 167-172

    • NAID

      130004551367

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 妊娠と医薬品使用に関する問い合わせ内容の調査2012

    • Author(s)
      小原拓, 尾崎芙実, 吉中千佳, 前川真央, 草場美津江, 石黒真美, 飯田優太郎, 鈴木文子,松浦正樹, 佐賀利英, 佐藤真由美, 久道周彦, 島田美樹, 栗山進一, 八重樫伸生, 眞野成康
    • Journal Title

      医薬品相互作用研究

      Volume: 35 Pages: 17-21

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] シンバスタチン服用前後の脂質・血糖・血圧の変化:市販後調査データを用いた検討2012

    • Author(s)
      小原拓, 猪狩有紀恵, 小林寛子, 高橋武, 高橋則男, 岸川幸生, 村井ユリ子, 眞野成康, 高橋將喜
    • Journal Title

      医薬品相互作用研究

      Volume: 36 Pages: 15-20

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pharmacists’ Awareness and Attitude toward Blood Pressure Measurement at Home and in the Pharmacy in Japan2012

    • Author(s)
      Obara T, Ohkubo T, Tanaka K, Satoh M, Ishikura K, Kobayashi M, Metoki H, Asayama K, Kikuya M, Murai Y, Mano N, Oide S, Imai Y
    • Journal Title

      Clin Exp Hypertens

      Volume: 34 Pages: 290-296

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 小児における副作用発生状況の評価2014

    • Author(s)
      小原拓、佐藤倫広、西郡秀和、村井ユリ子、 眞野成康、八木直人
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき明星大学キャンパス(福島県いわき市)
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 小児における医薬品使用と安全性情報の評価2014

    • Author(s)
      佐藤倫広、小原拓、西郡秀和、村井ユリ子、 眞野成康、八木直人
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき明星大学キャンパス(福島県いわき市)
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] レセプトデータに基づく妊娠中の医薬品使用と児の先天奇形との関連に関する検討2014

    • Author(s)
      小原拓、西郡秀和、目時弘仁、眞野成康、八重樫伸生、栗山進一
    • Organizer
      第3回日本DOHaD研究会学術集会
    • Place of Presentation
      国立成育医療研究センター(東京都世田谷区)
    • Year and Date
      2014-07-25 – 2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] エコチル調査・宮城ユニットセンターにおける妊婦の医薬品使用状況の評価-宮城ユニットセンター薬剤詳細調査より-2014

    • Author(s)
      西郡秀和、小原拓、目時弘仁、石黒真美、水野聖士、櫻井香澄、岩間憲之、村井ユリ子、杉山隆、菅原準一、眞野成康、栗山進一、八重樫伸生
    • Organizer
      第3回日本DOHaD研究会学術集会
    • Place of Presentation
      国立成育医療研究センター(東京都世田谷区)
    • Year and Date
      2014-07-25 – 2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 妊娠中の医薬品使用と児の先天奇形との関連:レセプトデータに基づく検討2014

    • Author(s)
      小原拓、佐藤倫広、西郡秀和、目時弘仁、大久保孝義、赤沢学、八重樫伸生、栗山進一、眞野成康
    • Organizer
      第17回日本医薬品情報学会総会・学術大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Year and Date
      2014-07-12 – 2014-07-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prescription of Drugs during Pregnancy in Japan2012

    • Author(s)
      Obara T, Akazawa M, Ohkubo T, Ishikuro M, Metoki H, Shono A, Nishigori H, Mano N, Yaegashi N, Kuriyama S
    • Organizer
      28th International Conference on Pharmacoepidemiology & Therapeutic Risk Management.  (ISPE)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] Prescription of drugs for children with attention deficit/hyperactivity disorder (AD/HD) in Japan2012

    • Author(s)
      Obara T, Ooba N, Morikawa Y, Ishikuro M, Metoki H, Kikuya M, Nishigori H, Mano N, Kuriyama S
    • Organizer
      The 7th Asian Conference on Pharmacoepidemiology (ACPE 7) meeting
    • Place of Presentation
      Bangalore, India
    • Related Report
      2012 Research-status Report
  • [Presentation] レセプトデータに基づく妊娠中の医薬品使用状況の把握に関する研究2012

    • Author(s)
      小原拓, 石黒真美, 目時弘仁, 西郡秀和, 大久保孝義, 眞野成康, 八重樫伸生, 栗山進一
    • Organizer
      第15回 日本医薬品情報学会 総会・学術大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] 妊婦における医薬品使用の現状2012

    • Author(s)
      小原拓
    • Organizer
      日本病院薬剤師会東北ブロック第2回学術大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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