| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We investigated the anti-inflammatory activity of PXR in a mouse model of immune-mediated liver injury induced by concanavalin A (Con A). In this model, PXR knockout mice displayed augmented liver damage compared with wild-type mice. Pretreatment of wild-type mice with PCN, a potent mouse PXR activator, prior to Con A challenge led to an amelioration of liver injury, which was accompanied by reduction of Con A-induced chemokine mRNA expression and neutrophil infiltration. These data suggest that PXR protects liver from Con A-induced injury by repressing the hepatic immune response.
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