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Biomarker discovery for chemotherapy-induced peripheral neuropathy

Research Project

Project/Area Number 24790143
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionTohoku University

Principal Investigator

SUZUKI NAOTO  東北大学, 薬学研究科(研究院), 准教授 (60372299)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords末梢神経障害 / バイオマーカー
Research Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe dose-limiting side effect of anticancer drugs because of the lack of effective care. The aim of this study was to discover the biomarkers for early diagnosis and optimal care of CIPN using NGF-differentiated PC12D cells. After treatment with anticancer drugs such as oxaliplatin, paclitaxel and bortezomib, intracellular metabolites were extracted and analyzed by liquid chromatography/mass spectrometry (LC/MS). LC/MS analysis revealed some characteristic changes in the concentration of intracellular metabolites related to treatment with specific types of anticancer drugs.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry2012

    • Author(s)
      Saigusa D, Shiba K, Inoue A, Hama K, Okutani M, Iida N, Saito M, Suzuki K, Kaneko T, Suzuki N, Yamaguchi H, Mano N, Goto J, Hishinuma T, Aoki J, Tomioka Y
    • Journal Title

      Anal Bioanal Chem

      Volume: 403 Issue: 7 Pages: 1897

    • DOI

      10.1007/s00216-012-6004-9

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 抗悪性腫瘍薬に対する生体反応解明のための網羅的代謝物解析2013

    • Author(s)
      鈴木直人
    • Organizer
      第24回日本臨床化学会東北支部総会
    • Place of Presentation
      仙台
    • Year and Date
      2013-07-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト肝細胞癌細胞株HepG2に対する鉄キレート剤デフェロキサミンの作用機序解明に向けた非標的メタボローム解析2013

    • Author(s)
      杉山栄二、鈴木直人
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 抗悪性腫瘍薬に対する生体反応解明のための網羅的代謝物解析

    • Author(s)
      鈴木直人
    • Organizer
      第24回日本臨床化学会 東北支部総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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