Analysis of thrombocytopenia of molecular target drug by realtime culture cells analysis device with iPS cells

• Project/Area Number: 24790144
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Gunma University
• Principal Investigator: HASHITA Tadahiro 群馬大学, 医学(系)研究科(研究院), 助教 (20613384)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 血小板減少 / iPS細胞 / 分子標的治療薬 / 巨核球 / リアルタイム培養細胞解析装置

Research Abstract

The aim of this study is to elucidate the mechanism of thrombocytopenia by molecular target drug. In this study, we found the decrease of CD33 positive cells by VEGF. Therefore, we found the differentiation to megakaryocyte differed by the differentiative medium. At present, we continue to study with megakaryocytes.