| Project/Area Number |
24790153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
Tsugane Mamiko 大阪大学, 薬学研究科(研究院), 招へい教員 (00469991)
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| Project Period (FY) |
2013-02-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 抗HIV薬 / 脂質代謝異常 / 11β-HSD1 / 臨床薬学 |
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| Outline of Final Research Achievements |
The principal aim of the present study was to determine the mechanism of dyslipidemia, which occurs during the long-term use of anti-HIV drugs. We investigated patient background information based on medical records, clinical test values, and drug use in HIV-infected patients, and evaluated the activity of the glucocorticoid-activating enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in urine samples using liquid chromatography/mass spectrometry. Our results revealed high activity of 11β-HSD1 according to the urine metabolite data in patients who used antidyslipidemic drugs combined with anti-HIV drugs and in patients with increased blood low-density lipoprotein levels after the use of anti-HIV drugs. These results suggest that 11β-HSD1 is involved in anti-HIV drug-related dyslipidemia.
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