| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Hyperuricemia, begins with induction of oxidative stress which closely related to the renin angiotensin system, is related to the onset and the progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). Therefore, reduction of oxidative stress is important in hyperuricemia. In the present study, we evaluate the antioxidant effects of uricosuric agent benzbromarone. As a result, Benzbromarone has a direct radical scavenging activity against superoxide radicals and reduced oxidative stress induced by angiotensin II in the endothelial cell. Furthermore, benzbromarone exerts a direct antioxidant action in angiotensin II and salt induced-hypertension model rats. These results revealed that benzbromarone exerts a direct antioxidant action in the body. It is expected in the future that benzbromarone may be useful agent as a multiple antioxidants for the prevention of CVD and CKD.
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