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Development of novel nanocarrier for follicular delivery

Research Project

Project/Area Number 24790163
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

UCHINO Tomonobu  静岡県立大学, 薬学部, 講師 (40345228)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsベシクル / 毛包デリバリー / 経皮吸収 / 毛包
Outline of Final Research Achievements

In current study, sucrose laurate based vesicles were prepared. Drug loading into the vesicle resulted in the enhancement of drug skin permeation. By the application of coumarin-6 loaded in the vesicle on the skin, accumulation of coumarin-6 was observed into hair follicles. Our vesicle formulations are prepared using additives which is including the Japanese Pharmaceutical Excipients or Japanese Cosmetic Ingredients Codex. Therefore, it might be effective nanocarrier of transdermal delivery for the clinical application as hospital preparation. However, more investigation will be needed including formulation change for highly transitivity into the hair follicles and skin irritation test of vesicle formulations. It would be strongly expected for further development of this research.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Transdermal delivery of flurbiprofen from surfactant-based vesicles: particle characterization and the effect of water on in vitro transport2014

    • Author(s)
      Tomonobu Uchino, Yuiko Matsumoto, Akiko Murata, Toshihiko Oka, Yasunori Miyazaki, Yoshiyuki Kagawa
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 464 Issue: 1-2 Pages: 75-84

    • DOI

      10.1016/j.ijpharm.2013.12.051

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Transdermal delivery of flurbiprofen from surfactant-based vesicles: Particle characterization and the effect of water on in vitro transport2014

    • Author(s)
      Tomonobu Uchino*, Yuiko Matsumoto, Akiko Murata, Toshihiko Oka, Yasunori Miyazaki and Yoshiyuki Kagawa
    • Organizer
      5th FIP Pharmaceutical Sciences World Congress
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-04-13 – 2014-04-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 尋常性ざ瘡治療を目的としたノビレチン外用剤の開発 -ノビレチン可溶化手法の検討-2013

    • Author(s)
      佐々木 彩乃、内野 智信、宮嵜 靖則、賀川 義之
    • Organizer
      第23回医療薬学会年会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2013 Research-status Report
  • [Presentation] 尋常性ざ瘡治療を目的としたノビレチン外用剤の開発 -ノビレチン可溶化手 法の検討-2013

    • Author(s)
      佐々木 彩乃、内野 智信、宮嵜 靖則、賀川 義之
    • Organizer
      第23回医療薬学会年会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] フルルビプロフェン封入ベシクルの調製とキャラクタリゼーション2012

    • Author(s)
      松本 ゆいこ、内野 智信、宮嵜 靖則、賀川 義之
    • Organizer
      第22回医療薬学会年会
    • Place of Presentation
      ときメッセ(新潟)
    • Related Report
      2013 Research-status Report
  • [Presentation] フルルビプロフェン封入ベシクルの調製と そのキャラクタリゼーション2012

    • Author(s)
      松本 ゆいこ、内野 智信、宮嵜 靖則、賀川 義之
    • Organizer
      第22回医療薬学会年会
    • Place of Presentation
      ときメッセ(新潟)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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