Evaluation of circulating miRNA in exosomes for novel biomarker of arteriosclerosis
Project/Area Number |
24790164
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | Nagoya City University |
Principal Investigator |
IWAKI Soichiro 名古屋市立大学, 薬学研究科(研究院), 講師 (60399962)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | miRNA / バイオマーカー / 動脈硬化症 / 動脈硬化 |
Research Abstract |
To identify the novel miRNA markers for arteriosclerosis, we first screened total RNA samples derived from patient's plasma using a microarray platform. As a result, several circulating miRNAs were identified to be differentially expressed. We also demonstrated that optimal RNA extraction method of miRNA from human plasma samples for quantitative PCR. These results suggest that circulating miRNAs are available as a novel biomarker to assess the arteriosclerosis.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Increased Plasma Sphingosine-1-Phosphate in Obese Subjects and Its Capacity to Increase Expression of Plasminogen Activator Inhibitor-1 in Adipocytes2013
Author(s)
Shiori Ito, Soichiro Iwaki, Keiko Koike, Yuichiro Yuda, Ayako Nagasaki, Ryunosuke Ohkawa, Yutaka Yatomi, Tomoo Furumoto, Hiroyuki Tsutsui, Burton E Sobel, Satoshi Fujii
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Journal Title
Coron. Artery Dis
Volume: 24
Issue: 8
Pages: 642-650
DOI
Related Report
Peer Reviewed
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[Journal Article] Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB.2013
Author(s)
Mizutani N, Kobayashi M, Sobue S, Ichihara M, Ito H, Tanaka K, Iwaki S,Fujii S,Ito Y, Tamiya-Koizumi K, Takagi A, Kojima T, Naoe T, Suzuki M, Nakamura M, Banno Y, Nozawa Y, Murate T.
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Journal Title
Biochimica et Biophysica Acta -Molecular Cell Research
Volume: 1833
Issue: 5
Pages: 1006-16
DOI
Related Report
Peer Reviewed
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