Mechanism of hypotaurine transport by Slc6a13 for oxidative stress defense
| Project/Area Number |
24790171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
HIGUCHI Kei 帝京大学, 薬学部, 助教 (10625304)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ヒポタウリン / 酸化ストレス / Slc6a13 / 細胞保護効果 / 抗アポトーシス / エズリン |
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| Research Abstract |
We clarified the protective effect of hypotaurine on TR-TBT18d-1 cells, rat placental cell line, exposed with oxidative stress. This study suggested that anti-hydroxyradical and -peroxyradical effects were involved in the protective effect of hypotaurine. Interestingly, the expression of rodent Slc6a13, which is a GABA transporter and express in peripheral organs such as placenta, was contributed to the protection against the oxidative stress and apoptosis induced by hydrogen peroxide.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] System amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts.2014
Author(s)
Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Takahashi Y, Okazaki F, Sai Y, Higuchi, K, Maruyama T, Tomi M, Nakashima E
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Journal Title
Biochim Biophys Acta.
Volume: VOL. 1838
Issue: 5
Pages: 1306-12
DOI
Related Report
Peer Reviewed
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