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Mechanism of hypotaurine transport by Slc6a13 for oxidative stress defense

Research Project

Project/Area Number 24790171
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionTeikyo University

Principal Investigator

HIGUCHI Kei  帝京大学, 薬学部, 助教 (10625304)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsヒポタウリン / 酸化ストレス / Slc6a13 / 細胞保護効果 / 抗アポトーシス / エズリン
Research Abstract

We clarified the protective effect of hypotaurine on TR-TBT18d-1 cells, rat placental cell line, exposed with oxidative stress. This study suggested that anti-hydroxyradical and -peroxyradical effects were involved in the protective effect of hypotaurine. Interestingly, the expression of rodent Slc6a13, which is a GABA transporter and express in peripheral organs such as placenta, was contributed to the protection against the oxidative stress and apoptosis induced by hydrogen peroxide.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (10 results)

  • [Journal Article] System amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts.2014

    • Author(s)
      Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Takahashi Y, Okazaki F, Sai Y, Higuchi, K, Maruyama T, Tomi M, Nakashima E
    • Journal Title

      Biochim Biophys Acta.

      Volume: VOL. 1838 Issue: 5 Pages: 1306-12

    • DOI

      10.1016/j.bbamem.2014.01.004

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical perfusion.2013

    • Author(s)
      Nishimura T, Takanohashi T, Tomi M, Horikoshi M, Higuchi K, Sai Y, Nakashima E.
    • Journal Title

      J Pharm Sci

      Volume: 102(9) Issue: 9 Pages: 3356-3363

    • DOI

      10.1002/jps.23551

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells.2013

    • Author(s)
      Oda K, Nishimura T, Higuchi K, Ishido N, Ochi K, Iizasa H, Sai Y, Tomi M, Nakashima E.
    • Journal Title

      J Pharm Sci

      Volume: 102 Issue: 9 Pages: 3364-3372

    • DOI

      10.1002/jps.23549

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Slc6a13を介した胎盤へのヒポタウリン供給が示す抗酸化作用2013

    • Author(s)
      杉田友紀、Mariam Duereh、樋口慧、西村友宏、崔吉道、登美斉俊、中島恵美
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Slc6a13を介した胎盤へのヒポタウリン供給が示す抗酸化作用.2013

    • Author(s)
      杉田友紀、Mariam Duereh、樋口慧、西村友宏、崔吉道、登美斉俊、中島恵美.
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒポタウリンのヒドロキシラジカル消去活性による胎盤細胞保護効果2012

    • Author(s)
      Mariam Duereh、西村友宏、杉田友紀、樋口慧、登美斉俊、中島恵美
    • Organizer
      日本動物実験代替法学会第25回大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of ezrin on cellular localization and transport function of Slc6a132012

    • Author(s)
      Araki H, Higuchi K, Nishimura T, Sai Y, Tomi M, Nakashima E
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] EzrinがSlc6a13の細胞内局在および輸送機能に与える影響2012

    • Author(s)
      荒木光,樋口慧,西村友宏,崔吉道,登美斉俊,中島恵美
    • Organizer
      第7回トランスポーター研究会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒポウリタンによるヒドロキシラジカルからの胎盤細胞保護効果2012

    • Author(s)
      Mariam Duereh,樋口慧,杉田友紀,西村友宏,登美斉俊,中島恵美
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒポウリタンによるヒドロキシラジカルからの胎盤細胞保護効果.2012

    • Author(s)
      Mariam Duereh, 樋口慧, 杉田友紀, 西村友宏, 登美斉俊, 中島恵美.
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] EzrinがSlc6a13の細胞内局在および輸送機能に与える影響.2012

    • Author(s)
      荒木光, 樋口慧, 西村友宏, 崔吉道, 登美斉俊, 中島恵美.
    • Organizer
      第7回トランスポーター研究会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of ezrin on cellular localization and transport function of Slc6a13.2012

    • Author(s)
      Araki H, Higuchi K, Nishimura T, Sai Y, Tomi M, Nakashima E.
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒポタウリンのヒドロキシラジカル消去活性による胎盤細胞保護効果.2012

    • Author(s)
      Mariam Duereh、西村友宏、杉田友紀、樋口慧、登美斉俊、中島恵美.
    • Organizer
      日本動物実験代替法学会第25回大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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