| Project/Area Number |
24790172
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Research Collaborator |
古田 隆 東京薬科大学, 臨床薬学教室, 教授
柴崎 浩美 東京薬科大学, 臨床薬学教室, 准教授
山田 明 杏林大学医学部, 第一内科学教室, 教授
川嶋 聡子 杏林大学医学部, 第一内科学教室
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | コルチゾール / コルチゾン / 11β-HSD2 / 腎疾患 / 本態性高血圧 / 酵素活性 / 11β-HSD |
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| Outline of Final Research Achievements |
In this study, the relationship between 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) enzyme activity and blood pressure was evaluated using the new index of in vivo human 11β-HSD2 activity that was developed in our laboratory (urinary ratio of free cortisone to cortisol correlated with the urinary concentration of cortisol, which is represented as UFE/UFF-cortisol concentration). Among 70 patients with renal disease, eight patients exhibited decreased 11β-HSD2 activity as indicated by the UFE/UFF-cortisol concentration. These patients had high diastolic blood pressure, suggesting that decreases in 11β-HSD2 activity contribute to the elevated blood pressure in patients with renal disease.
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