| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Intestinal atrophy and hepatic injury with the decrease of drug-metabolizing enzyme were induced by the long-term parenteral nutrition (PN) treatment in rats. The pharmacokinetic studies were conducted with intravenous and intraintestinal administrations of various compounds to this PN rats. Compared to control rats, a compound that is predominantly eliminated by kidney showed no significant alterations after intravenous administration, but represented the enhanced intestinal permeability after intraintestinal administration to PN rats. On the other hand, a compound that is mainly metabolized by liver produced the higher systemic exposure after intravenous administration, whereas maintained the comparable intestinal permeability after intraintestinal administration. The present study revealed that the pharmacokinetic alterations induced by long-term PN depend on the administration route and pharmacokinetic properties of a drug, which should be considered in the clinical setting.
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