Pharmacokinetic assessment of intestinal atrophy induced by long-term parenteral nutrition
| Project/Area Number |
24790178
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 薬物動態 / 消化管萎縮 / 経腸静脈栄養 / 吸収 / 代謝 / TPN / 薬物代謝 / バンコマイシン / P糖タンパク / 薬物代謝酵素 / 中心静脈栄養 / 小腸萎縮 / 栄養療法 |
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| Outline of Final Research Achievements |
Intestinal atrophy and hepatic injury with the decrease of drug-metabolizing enzyme were induced by the long-term parenteral nutrition (PN) treatment in rats. The pharmacokinetic studies were conducted with intravenous and intraintestinal administrations of various compounds to this PN rats. Compared to control rats, a compound that is predominantly eliminated by kidney showed no significant alterations after intravenous administration, but represented the enhanced intestinal permeability after intraintestinal administration to PN rats. On the other hand, a compound that is mainly metabolized by liver produced the higher systemic exposure after intravenous administration, whereas maintained the comparable intestinal permeability after intraintestinal administration. The present study revealed that the pharmacokinetic alterations induced by long-term PN depend on the administration route and pharmacokinetic properties of a drug, which should be considered in the clinical setting.
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Report
(4 results)
Research Products
(5 results)
