Research on the food-drug interaction focused on the nuclear receptor PPAR gamma
| Project/Area Number |
24790182
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
YOSHIDA Hiroki 九州保健福祉大学, 薬学部, 講師 (90469411)
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| Research Collaborator |
KUROKAWA Masahiko 九州保健福祉大学, 薬学部薬学科, 教授 (80186527)
WATANABE Wataru 九州保健福祉大学, 薬学部薬学科, 教授 (50399218)
SUGIRA Chihiro 九州保健福祉大学, 薬学部薬学科, 助教 (70632694)
ATSUMI Toshiyuki 九州保健福祉大学, 薬学部薬学科, 助教 (60453651)
NARUMI Keiko 九州保健福祉大学, 薬学部薬学科, 助教 (40551304)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 核内受容体 / PPARγ / 食品 / 医薬品 / 相互作用 / ナリンゲニン / ピオグリタゾン / 糖尿病 / フラボノイド |
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| Outline of Final Research Achievements |
We analyzed the interaction between ordinary food factors and anti-diabetic drug pioglitazone on the activation of PPAR gamma and the improvement of diabetes. Citrus flavonoid naringenin increased pioglitazone-induced PPAR gamma activation in vitro using a cell culture system. However, naringenin reduced the anti-diabetic effect of pioglitazone in vivo using a pathological mouse model. Naringenin did not affect serum pioglitazone concentration. In contrast, naringenin slightly affected the PPAR gamma-cofactors complex formation.
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Report
(4 results)
Research Products
(21 results)
