Analysis of autophagy in myogenesis and skeletal muscle regeneration
| Project/Area Number |
24790190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Gunma University |
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Principal Investigator |
UENO Hitoshi 群馬大学, 医学(系)研究科(研究院), 助教 (30586251)
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| Research Collaborator |
MORIMURA Yosihiro
MATSUDA Haruko
SUNOHARA Yukiko
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | オートファジー / 骨格筋形成 / 骨格筋再生 / 骨格筋の形成・修復 / LC3 / p63 / 筋形成・再生 |
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| Outline of Final Research Achievements |
I analyzed the autophagy in the regeneration and the formation of the skeletal muscle. By the experiment of the regeneration, expression of LC3 increased after the damage of the skeletal muscle immediately and LC3 formed a small vesicle. Autophagosome was few in a myoblasts at the time of the skeletal muscle formation, but autophagosome was increased after differentiation, and autophagosome were become autolysosome when myoblasts differentiated into myotubes. These results suggested that the autophagy played an important role in the regeneration and the formation of the skeletal muscle.
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Report
(4 results)
Research Products
(18 results)
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[Presentation] 群馬大学におけるCTを用いた解剖学教育体制と放射線科診断医としての取り組み.2014
Author(s)
粟田さち子, 依藤 宏, 村上 徹, 多鹿 友喜, 上野 仁之, 小湊慶彦, 平澤 聡, 小林 進, 島田 健裕, 徳江浩, 対馬義人
Organizer
第119回日本解剖学会総会・全国学術集会
Place of Presentation
自治医科大学
Related Report
Invited
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