Cell fate specification in gastrointestinal epithelial cells by helix-loop-helix factor Id2
| Project/Area Number |
24790194
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | University of Fukui |
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Principal Investigator |
MORI Kentaro 福井大学, 医学部, 助教 (50397296)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 細胞分化 / 消化管上皮 / 内胚葉 / 転写因子 / Id2 / Irx3 / Irx5 / 消化管 / 上皮細胞 / 国際情報交換 |
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| Research Abstract |
Gastrointestinal epithelial cells are derived from endoderm, and region-specific endoderm differentiation establishes the functionally distinct organ, esophagus, stomach and caudally positioned intestine. How region-specific epithelial characteristics are generated during development remains poorly understood. I have found that the knockout mice of transcriptional repressor Id2 develop intestinal tumors, and revealed that the tumors are derived from ectopic gastric tissues formed in the small intestine during development. This study demonstrates that Id2 is involved in the cell fate specification of the intestinal epithelial cells through the suppression of the foregut endoderm genes expression.
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Report
(3 results)
Research Products
(15 results)
