Hepatoblasts might contribute to hepatic sinusoidal endothelial cells development

Research Project

Project/Area Number	24790197
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General anatomy (including Histology/Embryology)
Research Institution	Kumamoto University
Principal Investigator	NIKI Daisuke 熊本大学, 生命資源研究・支援センター, 厚労科研研究員 (10621914)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	肝芽細胞 / 肝類洞内皮細胞 / 肝臓発生
Research Abstract	Hepatic sinusoidal endothelial cells are an important roles for hepatic development and regeneration, control of blood flow in liver and immunoreaction. However, developmental mechanism of hepatic sinusoidal endothelial cells is not a little known. Based on several literatures, we formulated a hypothesis which hepatoblasts might contribute hepatic sinusoidal endothelial cells development. In order to examine the hypothesis, we generated Hhex knockout mice as hepatoblasts-less liver mice. Hereafter, development of hepatic sinusoidal endothelial cells and roles of hepatoblasts are examined using Hhex knockout mice.