Investigation into the mechanism of neurogenic hypertension: Approach from the cardio-respiratory relationship
| Project/Area Number |
24790206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 高血圧 / 交感神経 / 循環中枢 / 呼吸中枢 / GABA / グリシン / ATP / 低酸素 / 循環調節 |
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| Outline of Final Research Achievements |
It has been suggested that congenital enhancement of the cardiovascular sympathetic nerve activity causes neurogenic hypertension. However, the mechanism is still unclear. In this study, with focusing on the respiratory activity of the sympathetic nerve, we tried to analyze the mechanism of neurogenic hypertension which is related with enhancement of the sympathetic nerve activity. As the result, we found the presence of respiratory phase related inhibitory regulation of neurons in the cardiovascular center, and ATP related inhibitory modulation of neurons in the cardiovascular center under condition of hypoxia. This result might be very useful to investigate details of the mechanism of neurogenic hypertension.
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Report
(4 results)
Research Products
(6 results)
