| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
It has been suggested that congenital enhancement of the cardiovascular sympathetic nerve activity causes neurogenic hypertension. However, the mechanism is still unclear. In this study, with focusing on the respiratory activity of the sympathetic nerve, we tried to analyze the mechanism of neurogenic hypertension which is related with enhancement of the sympathetic nerve activity. As the result, we found the presence of respiratory phase related inhibitory regulation of neurons in the cardiovascular center, and ATP related inhibitory modulation of neurons in the cardiovascular center under condition of hypoxia. This result might be very useful to investigate details of the mechanism of neurogenic hypertension.
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