Molecular mechanism and pathophysiology of nucleophagy induced by cation pump
| Project/Area Number |
24790209
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | University of Toyama |
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Principal Investigator |
FUJII Takuto 富山大学, 大学院医学薬学研究部(薬学), 助教 (50567980)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 生理学 / 細胞 / 細胞死 / P型ATPase / オートファジー / ヌクレオファジー |
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| Research Abstract |
In this research, the molecular mechanism and pathophysiology of nucleophagy induced by human ATP13A4 were examined. We found that human ATP13A4 had no ion-transporting function and its N-terminal region was essential for induction of nucleophagy. On the other hand, mouse ATP13A4 had cation-transporting function and did not induce nucleophagy. Related proteins for the ATP13A4-induced nucleophagy were identified by DNA microarray and proteomics. Especially, increased expression levels of proteins involved in proteolytic system and cellular stress response were observed in human ATP13A4-expressing cells.
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Functional coupling of chloride-proton exchanger C1C-5 to gastric H +, K <+->ATPase.2014
Author(s)
Takahashi Y, Fujii T, Fujita K, Shimizu T, Higuchi T, Tabuchi Y, Sakamoto H, Naito I, Manabe K, Uchida S, Sasaki S, Ikari A, Tsukada K, Sakai H.
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Journal Title
Biol. Open
Volume: 3巻
Issue: 1
Pages: 12-21
DOI
Related Report
Peer Reviewed
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