Analysis of molecular mechanisms underlying regulation of basal activity of t-tubular L-type Ca channels in ventricular myocytes
Project/Area Number |
24790210
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General physiology
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Research Institution | Shinshu University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | L型カルシウムチャネル / 心筋 / タンパク質リン酸化酵素 / 心不全 / T管 / 興奮収縮連関 / プロテインホスファターゼ2A / カゼインキナーゼ2 |
Research Abstract |
Despite recently advanced medical therapies, heart failure is one of the leading risks of death in developed nations. T-tubular L-type Ca2+ channels (LTCC) in ventricular myocytes play a crucial role in cardiac excitation-contraction coupling. Decreased basal activity of t-tubular LTCC is involved in cardiac disfunction. We recently found that basal activity of LTCC is supported by casein kinase 2 (CK2). Here, I examined the molecular mechanisms underlying regulation of basal LTCC activity by CK2. In the result, I found that CK2a'b determines the basal activity of cardiac LTCC.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Novel regulation pf cardiac metabolism and homeostasis by the adrenomedullin- receptor activity-modifying protein 2 system2013
Author(s)
Takahiro Yoshizawa, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Yasuhiro Iesato, Teruhide Koyama, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Tsutomu Nakada, Toshihide Kashihara, Mitsuhiko Yamada, Hayato Kawakami, Hiroki Nakanishi, Ryo Taguchi, Tsuyoshi Nakanishi, Hiroshi Akazawa, Takayuki Shindo
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Journal Title
Hypertension
Volume: 61
Issue: 2
Pages: 341-351
DOI
Related Report
Peer Reviewed
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[Journal Article] Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice2012
Author(s)
Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M
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Journal Title
PLoS One
Volume: 7
Issue: 12
Pages: e52667-e52667
DOI
Related Report
Peer Reviewed
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