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Modeling analysis on the molecular mechanisms underlying insulinotropic effects of incretin hormone in pancreatic beta cells.

Research Project

Project/Area Number 24790211
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionRitsumeikan University

Principal Investigator

TAKEDA Yukari  立命館大学, 生命科学部, 助教 (20582159)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords受容体・細胞内シグナル伝達
Outline of Final Research Achievements

Upon elevation of plasma glucose concentration, pancreatic β-cells generate bursts of action potentials to induce cyclic changes in [Ca2+]i and regulate pulsatile insulin release. This glucose-dependent insulin secretion is synergistically enhanced by an incretin hormone, GLP-1. To date, it has been well established that GLP-1 increases [cAMP] and subsequently activates PKA and Epac, modulating the activities of ion channels at the plasma membrane and ER, which in turn modify the pattern of burst as well as Ca2+ mobilization events. However, because of complex interactions between multiple cellular factors and ion channels or transporters involved in the GLP-1 effects, quantitative aspects of the molecular mechanisms have not yet been determined. In order to overcome this difficulty, we adopted a strategy of modeling analysis; simulation study and mathematical analysis, and quantitatively investigated the mechanisms underlying the GLP-1 effects on cellular functions.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2012 Other

All Journal Article (1 results) Presentation (14 results)

  • [Journal Article] β細胞におけるGLP-1受容体を介するcAMP制御機構の数理モデル化とシミュレーション研究2012

    • Author(s)
      竹田有加里、稲垣暢也
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 35(2) Pages: 141-148

    • Related Report
      2012 Research-status Report
  • [Presentation] Theoretical analyses of inositol 1,4,5-trisphosphate receptors (IP3R)-mediated calcium mobilization from intracellular stores in pancreatic beta cells.2015

    • Author(s)
      竹田有加里、嶋吉隆夫、George G.Holz、野間 昭典
    • Organizer
      日本薬学会第135年会 シンポジウム
    • Place of Presentation
      神戸学院大学(兵庫県)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Modeling Analysis of Glucagon-like peptide-1 (GLP-1)-induced Inositol 1,4,5-trisphosphate Receptor (IP3R)-Mediated Ca2+ liberation in Pancreatic β-Cells.2015

    • Author(s)
      竹田有加里、野間 昭典
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] MODELING ANALYSIS OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR (IP3R)-MEDIATED CA2+ MOBILIZATION FROM INTRACELLULAR CA2+ STORES IN PANCREATIC BETA CELLS.2014

    • Author(s)
      Yukari Takeda, Takao Shimayoshi, George G. Holz, Akinori Noma
    • Organizer
      10th IDF-WPR Congress &6th AASD Scientific Meeting
    • Place of Presentation
      Singapore (Singapore)
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 膵β細胞におけるイノシトール三リン酸受容体(IP3R)を介するCa2+動態の数理モデル化及びそのメカニズム解析2014

    • Author(s)
      竹田有加里、野間 昭典
    • Organizer
      第107回近畿生理学会談話会
    • Place of Presentation
      兵庫医療大学(兵庫県)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] A simulation study of the effects of GLP-1 on membrane excitability in pancreatic beta-cells

    • Author(s)
      Yukari Takeda
    • Organizer
      International Union of Physiological society (37th)
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Research-status Report
  • [Presentation] 強光下の光応答再現可能な杆体・錐体視細胞光電位変換機構モデルの提案

    • Author(s)
      細木ゆかり
    • Organizer
      視覚科学フォーラム
    • Place of Presentation
      立命館大学 (滋賀県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 杆体・錐体視細胞光電位変換機構モデルによる視物質-トランスデューシンシグナル増幅現象の再現

    • Author(s)
      細木ゆかり
    • Organizer
      生体医工学シンポジウム
    • Place of Presentation
      九州大学 (福岡県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 膵β細胞におけるイノシトール三リン酸受容体(IP3R)を介するCa2+動態の数理モデル化とそのメカニズム解析

    • Author(s)
      竹田有加里
    • Organizer
      第106回近畿生理学会談話会
    • Place of Presentation
      奈良県立 医科大学 (奈良県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 膵β細胞におけるイノシトール三リン酸受容体(IP3R)を介するCa2+流動の数理モデル化とそのメカニズム解析

    • Author(s)
      竹田有加里
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学 (鹿児島県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Reproduction of Transducin Timecourse of Rod and Cone Cells under various Light Intensities

    • Author(s)
      Yukari Hosoki
    • Organizer
      International Union of Physiological society (37th)
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Research-status Report
  • [Presentation] 網膜杆体視細胞光電位変換機構モデルによる外節電流の再現

    • Author(s)
      細木ゆかり
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学 (鹿児島県)
    • Related Report
      2013 Research-status Report
  • [Presentation] A modeling analysis of GLP-1 Receptor Signaling in Pancreatic β-cells

    • Author(s)
      Yukari Takeda
    • Organizer
      9th IDF-WPR Congress & 4th AASD Scientific Meeting
    • Place of Presentation
      京都国際会館、京都府
    • Related Report
      2012 Research-status Report
  • [Presentation] A modeling analysis of GLP-1 effects on membrane excitability in Pancreaticβ-cells

    • Author(s)
      Yukari Takeda
    • Organizer
      Pancreatic β-cell Mini-Symposium: Innovative approaches to understanding pancreatic β-cell function
    • Place of Presentation
      立命館大学BKCエポック立命21、滋賀県
    • Related Report
      2012 Research-status Report
  • [Presentation] 膵β細胞におけるGLP-1受容体を介するcAMP制御機構のシミュレーション研究

    • Author(s)
      竹田有加里
    • Organizer
      第105回近畿生理学会談話会
    • Place of Presentation
      関西医科大学滝井学舎、大阪府
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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