| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The contractile function in the heart results from the accurate propagation of action potentials in cardiomyocytes. The voltage-gated sodium (Na) channels, playing key roles in the action potential initiation and the propagation, alters the distribution within a myocyte in congenital and acquired disorder. We considered effects of changes in subcellular Na channel distribution on the occurrence of lethal arrhythmia. Using computer simulation, we showed that the conduction disorder and the initiation of reentrant tachyarrhythmia may be partly attributable to the subcellular Na channel distribution. These results suggest that not only the function of ion channels but also the subcellular distribution may be partly responsible for the occurrence of lethal arrhythmia.
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