| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Research Abstract |
Vagal afferents sense the peripheral factors, convey this neural information to the brain, thereby regulating feeding. However, it is not clear that what kinds of factors act on the vagal afferents directly and what kinds of neurotransmitters which are released from the vagus terminals to the nucleus tractus solitaries (NTS) contribute to regulate food intake.
The present study demonstrates that insulin, pancreatic polypeptide, peptide YY3-36, and oxytocin directly act on the isolated vagal afferent neurons, and these effects are participated in decreasing food intake. CART peptide is putative neurotransmitter to decrease food intake, which is released from vagus terminals to NTS. Moreover, 12 genes in the NG changed the expression level more than twice between fasting and satiety, but it remains to be determined whether these gene-related molecules regulate food intake.
|
