Vagal afferent-mediated coupling of peripheral factor sensing to brain transmission and feeding regulation
| Project/Area Number |
24790221
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 求心性迷走神経 / nodose ganglion / 摂食 / insulin / pancreatic polypeptide / peptide YY / oxytocin / DNA microarray / 延髄孤束核 / インスリン / オキシトシン / グレリン / 細胞内Ca |
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| Research Abstract |
Vagal afferents sense the peripheral factors, convey this neural information to the brain, thereby regulating feeding. However, it is not clear that what kinds of factors act on the vagal afferents directly and what kinds of neurotransmitters which are released from the vagus terminals to the nucleus tractus solitaries (NTS) contribute to regulate food intake.
The present study demonstrates that insulin, pancreatic polypeptide, peptide YY3-36, and oxytocin directly act on the isolated vagal afferent neurons, and these effects are participated in decreasing food intake. CART peptide is putative neurotransmitter to decrease food intake, which is released from vagus terminals to NTS. Moreover, 12 genes in the NG changed the expression level more than twice between fasting and satiety, but it remains to be determined whether these gene-related molecules regulate food intake.
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Report
(3 results)
Research Products
(30 results)
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[Presentation] Vagal afferent neurons sense pancreatic and plasma insulin: its impairment in hyperphasic obese mice2014
Author(s)
Iwasaki, Y., Shimomura, K., Kohno, D., Dezaki, K., Kakei, M., Nakata, M., and Yada, T.
Organizer
The 15th International Group on Insulin Secretion Symposia
Place of Presentation
フランス（ニース）
Related Report
Invited
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[Presentation] Insulin directly activates vagal afferent neurons through insulin signaling pathway and voltage-dependent Ca2+ influx2013
Author(s)
Iwasaki, Y., Shimomura, K., Ayush, E-A., Nakabayashi, H., Kubota, N., Kadowaki, T., Kakei, M., and Yada T.
Organizer
Neuro2013
Place of Presentation
京都府
Related Report
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