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Vagal afferent-mediated coupling of peripheral factor sensing to brain transmission and feeding regulation

Research Project

Project/Area Number 24790221
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionJichi Medical University

Principal Investigator

IWASAKI YUSAKU  自治医科大学, 医学部, 助教 (60528420)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords求心性迷走神経 / nodose ganglion / 摂食 / insulin / pancreatic polypeptide / peptide YY / oxytocin / DNA microarray / 延髄孤束核 / インスリン / オキシトシン / グレリン / 細胞内Ca
Research Abstract

Vagal afferents sense the peripheral factors, convey this neural information to the brain, thereby regulating feeding. However, it is not clear that what kinds of factors act on the vagal afferents directly and what kinds of neurotransmitters which are released from the vagus terminals to the nucleus tractus solitaries (NTS) contribute to regulate food intake.
The present study demonstrates that insulin, pancreatic polypeptide, peptide YY3-36, and oxytocin directly act on the isolated vagal afferent neurons, and these effects are participated in decreasing food intake. CART peptide is putative neurotransmitter to decrease food intake, which is released from vagus terminals to NTS. Moreover, 12 genes in the NG changed the expression level more than twice between fasting and satiety, but it remains to be determined whether these gene-related molecules regulate food intake.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report

Research Products

(30 results)

All 2014 2013 2012 Other

All Journal Article Presentation Book Remarks

  • [Journal Article] Insulin activates vagal afferent neurons including those innervating pancreas via insulin cascade and Ca^<2+> influx : Its dysfunction in IRS2-KO mice with hyperphagic obesity2013

    • Author(s)
      Yusaku Iwasaki
    • Journal Title

      Plos one

      Volume: 8

    • DOI
      10.1371/journal.pone.0067198
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic polypeptide and peptide YY_<3-36>induce Ca^<2+> signaling in nodose ganglion neurons2013

    • Author(s)
      Iwasaki Y, Kakei M, Nakabayashi H, Ayush EA, Hirano-Kodaira M, Maejima Y, Yada T
    • Journal Title

      Neuropeptides

      Volume: 47(1) Pages: 19-23

    • DOI
      10.1016/j.npep.2012.07.006
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 迷走神経による消化管情報の中枢伝達と摂食制御2013

    • Author(s)
      岩﨑有作、矢田俊彦
    • Journal Title

      G.I. Research

      Volume: 21 (1) Pages: 18-24

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 膵臓のインスリンを脳が感知する機序2013

    • Author(s)
      矢田俊彦、岩﨑有作
    • Journal Title

      日本医事新報

      Volume: 4677 Pages: 63-65

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Pancreatic polypeptide and peptide YY3-36 induce Ca2+ signaling in nodose ganglion neurons.2013

    • Author(s)
      Iwasaki, Y.
    • Journal Title

      Neuropeptides

      Volume: 47(1) Pages: 19-23

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vagal afferents sense meal-associated gastrointestinal and pancreatic hormones : mechanism and physiological role2012

    • Author(s)
      Iwasaki, Y. and Yada, T
    • Journal Title

      Neuropeptides

      Volume: 46(6) Pages: 291-297

    • DOI
      10.1016/j.npep.2012.08.009
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 消化管ホルモンの新機軸 : インスリン分泌抑制因子、臓器連関の伝令、DPP-4阻害薬標的の視点から2012

    • Author(s)
      中田正範、岩﨑有作、矢田俊彦
    • Journal Title

      Journal of Diabetes Strategy

      Volume: Vol.2 No.1 Pages: 24-30

    • Related Report
      2013 Final Research Report
  • [Journal Article] Vagal afferents sense meal-associated gastrointestinal and pancreatic hormones: mechanism and physiological role.2012

    • Author(s)
      Iwasaki, Y.
    • Journal Title

      Neuropeptides

      Volume: 46(6) Pages: 291-297

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Vagal afferent neurons sense pancreatic and plasma insulin : its impairment in hyperphasic obese mice2014

    • Author(s)
      Iwasaki, Y
    • Organizer
      The 15^<th> International Group on Insulin Secretion Symposia
    • Place of Presentation
      Nice, France
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵ホルモンは求心性迷走神経を介して脳に作用し、食欲を調節する2014

    • Author(s)
      岩﨑有作、矢田俊彦
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Vagal afferent neurons sense pancreatic and plasma insulin: its impairment in hyperphasic obese mice2014

    • Author(s)
      Iwasaki, Y., Shimomura, K., Kohno, D., Dezaki, K., Kakei, M., Nakata, M., and Yada, T.
    • Organizer
      The 15th International Group on Insulin Secretion Symposia
    • Place of Presentation
      フランス(ニース)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] インスリンはインスリンカスケードを介して求心性迷走神経を活性化し、過食・肥満を呈するIRS2欠損マウスではこの作用が障害される2013

    • Author(s)
      岩﨑有作
    • Organizer
      第12回自治医科大学シンポジウム
    • Place of Presentation
      栃木
    • Year and Date
      2013-09-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵臓を支配する求心性迷走神経は膵臓から分泌されるインスリンを効率良く受容する2013

    • Author(s)
      岩﨑有作
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Peripheral oxytocin activates vagal afferent neurons and thereby decreases food intake2013

    • Author(s)
      Iwasaki Y
    • Organizer
      The 36^<th> Naito Conference
    • Place of Presentation
      北海道
    • Related Report
      2013 Final Research Report
  • [Presentation] Insulin directly activates vagal afferent neurons through insulin signaling pathway and voltage-dependent Ca^<2+> influx2013

    • Author(s)
      Iwasaki, Y
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 単離求心性迷走神経細胞に対する膵ポリペプチドとペプチドYY_<3-36>の直接作用2013

    • Author(s)
      岩﨑有作
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      愛知
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵ポリペプチドとペプチドYY_<3-36>は求心性迷走神経細胞を直接活性化する2013

    • Author(s)
      岩﨑有作
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 単離求心性迷走神経細胞に対する膵ポリペプチドとペプチドYY3-36の直接作用2013

    • Author(s)
      岩﨑有作、加計正文、中林肇、Enkh-Amar Ayush、小平(平野)美里、前島裕子、矢田俊彦
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      愛知県
    • Related Report
      2013 Annual Research Report
  • [Presentation] Peripheral oxytocin activates vagal afferent neurons and thereby decreases food intake2013

    • Author(s)
      Yusaku Iwasaki, Yuko Maejima, Masahumi Kakei, Masashi Yoshida, Shiho Yamato, Hajime Nakabayashi, Toshihiko Yada,
    • Organizer
      The 36th Naito Conference
    • Place of Presentation
      北海道
    • Related Report
      2013 Annual Research Report
  • [Presentation] 膵臓を支配する求心性迷走神経は膵臓から分泌されるインスリンを効率良く受容する2013

    • Author(s)
      岩﨑有作、下村健寿、河野大輔、出崎克也、Enkh-Amar Ayush、中林肇、窪田直人、門脇孝、加計正文、中田正範、矢田俊彦
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Insulin directly activates vagal afferent neurons through insulin signaling pathway and voltage-dependent Ca2+ influx2013

    • Author(s)
      Iwasaki, Y., Shimomura, K., Ayush, E-A., Nakabayashi, H., Kubota, N., Kadowaki, T., Kakei, M., and Yada T.
    • Organizer
      Neuro2013
    • Place of Presentation
      京都府
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ghrelin attenuates insulin-induced activation of vagal afferent neurons of mice2012

    • Author(s)
      Iwasaki Y
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans, USA(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵ポリペプチドとペプチドYY_<3-36>の求心性迷走神経への直接作用2012

    • Author(s)
      岩﨑有作
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] インスリンの求心性迷走神経への直截作用、そのGLP-1による増強とグレリンによる抑制2012

    • Author(s)
      岩﨑有作
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      宮城
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Ghrelin attenuates insulin-induced activation of vagal afferent neurons of mice.2012

    • Author(s)
      Iwasaki, Y.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] インスリンはインスリンカスケードを介して求心性迷走神経を活性化し、過食・肥満を呈するIRS2欠損マウスではこの作用が障害される

    • Author(s)
      岩﨑有作、下村健寿、河野大介、出崎克也、Enkh-Amar Ayush、中林肇、窪田直人、門脇孝、加計正文、中田正範、矢田俊彦
    • Organizer
      第12回自治医科大学シンポジウム
    • Place of Presentation
      栃木県
    • Related Report
      2013 Annual Research Report
  • [Book] ホルモンと神経ペプチドによる摂食調節、Annual Review糖尿病・代謝・内分泌2012、寺内康夫、伊藤裕、石橋俊編集2012

    • Author(s)
      前島裕子、Sedbazar Udval、岩﨑有作、矢田俊彦
    • Publisher
      中外医学社、東京
    • Related Report
      2013 Final Research Report
  • [Remarks] 研究室ホームページにおける情報公開 ホームページ等

    • URL
      http://www.jichi.ac.jp/physio2/physiol_new_HP2008/index.htm
    • Related Report
      2013 Final Research Report
  • [Remarks] 自治医大生理学講座統合生理学部門ホームページ、メンバー紹介

    • URL
      http://www.jichi.ac.jp/physio2/physiol_new_HP2008/shoukai/yiwasaki.html
    • Related Report
      2013 Annual Research Report
  • [Remarks] 自治医科大学 研究シーズ集

    • URL
      http://rseeds.jichi.ac.jp/research_seeds/public/ResearchResultDetail.php?publicId=6eyq6cvs29v0a8twx9pdupgv9p2omm&resultCd=1&sectionCd=21
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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