A role of V1a receptor in water/electrolytes metabolism.
| Project/Area Number |
24790222
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | V1aR / collecting duct / acidosis / dehydration / V1a受容体 / 酸塩基調節 / 腎集合管 / V2R / AQP2 / アシドーシス / V1aR KOマウス / AP2 |
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| Outline of Final Research Achievements |
Arginine vasopressin (AVP) functions in the regulation of body fluid homeostasis, vasoconstriction, and ACTH release through vasopressin V1a, V1b (V3), and V2 receptors. We found that V1aR only localized in the intercalated cell (IC) type-A, type-B, non-A and non-B along the collecting duct (CD) in mouse kidney. The level of V1aR mRNA increased at the thick ascending limb (TAL) and IC of the CD in the inner stripe of the outer medulla after acid loading. V1aR may stimulate renal H＋ excretion and maintain the acid-base balance especially during the metabolic acidosis.
Furthermore, we have investigated the amount of AQP2 expression in WT and V1aR KO mice during euhydration and dehydration. The luminal expression of AQP2 significantly increased both in WT and V1aR KO during dehydration, although their levels of expression significantly decreased in V1aR KO mice. V1aR may contribute to water and electrolytes transport by maintaining the basal expression of AQP2 in kidney CD.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Effects of Atrial Natriuretic Peptide on Bicarbonate Transport in Long- and Short-Looped Medullary Thick Ascending Limbs of Rats.2013
Author(s)
Hiroshi Nonoguchi, Yuichiro Izumi, Yushi Nakayama, Takanobu Matsuzaki , Yukiko Yasuoka, Takeaki Inoue, Hideaki Inoue, Tomohiko Mouri, Katsumasa Kawahara, Hideyuki Saito, Kimio Tomita.
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Journal Title
PLOS one.
Volume: 8
Issue: 12
Pages: e83146-e83146
DOI
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Peer Reviewed
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[Presentation] Mechanisms of erythropoietin production by aldosterone in the intercalated cells
Author(s)
Yuichiro Izumi, Yukiko Yasuoka, Takanori Nagai, Kahori Hori, Yushi Nakayama, Masayoshi Nanami, Takeshi Nakanishi, Akito Tanoue, Kimio Tomita, Katsumasa Kawahara, Hiroshi Nonoguchi
Organizer
アメリカ腎臓学会
Place of Presentation
アトランタ
Related Report
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