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The role of PAI-1 in impaired osteoblast differentiation and function

Research Project

Project/Area Number 24790227
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionKinki University

Principal Investigator

TAMURA Yukinori  近畿大学, 医学部, 助教 (40580262)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords糖尿病 / 肥満 / 骨粗鬆症 / PAI-1 / 線溶系
Research Abstract

The present study examined the role of plasminogen activator inhibitor-1 (PAI-1), a principal inhibitor of fibrinolysis, in the pathogenesis of osteoporosis induced by type 1 diabetes and obesity with glucose metabolism abnormality using PAI-1-deficient mice. The bone loss occurred in both streptozotocin-induced type 1 diabetic and high-fat and high-sucrose diet-induced obese female mice. PAI-1 deficiency protected from the bone loss induced by type 1 diabetes, but not by obesity in female mice. On the other hand, the bone parameters such as bone mineral density and the levels of osteogenic genes were negatively correlated with the levels of circulating Tumor necrosis factor-alpha (TNF-alpha) in obese female mice. Taken together, our findings suggest that PAI-1 and TNF-alpha are involved in the pathogenesis of osteoporosis induced by type 1 diabetes and obesity, respectively.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] Plasminogen activator inhibitor-1 deficiency ameliorates insulin resistance and hyperlipidemia but not bone loss in obese female mice.2014

    • Author(s)
      Tamura Y, Kawao N, Yano M, Okada K, Matsuo O, Kaji H
    • Journal Title

      Endocrinology

      Volume: 155 Issue: 5 Pages: 1708-1717

    • DOI

      10.1210/en.2013-1888

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Influence of diabetic state and vitamin D deficiency on bone repair in female mice2014

    • Author(s)
      Mao L, Tamura Y, Kawao N, Okada K, Yano M, Okumoto K, Kaji H
    • Journal Title

      Bone

      Volume: 61 Pages: 102-108

    • DOI

      10.1016/j.bone.2013.12.024

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel factor, Tmem176b, induced by activin-like kinase 2 signal promotes the differentiation of myoblasts into osteoblasts2014

    • Author(s)
      Yano M, Kawao N, Tamur a Y, Okada K, Kaji H
    • Journal Title

      Exp Clin Endocrinol Diabet.

      Volume: 122 Pages: 7-14

    • URL

      https://www.jstage.jst.go.jp/article/endocrj/60/12/60_EJ13-0270/_article

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone and Wnt signaling2013

    • Author(s)
      Tamur a Y, Kaji H
    • Journal Title

      Clin Calcium

      Volume: 23(CliCa1306847852) Pages: 847-852

    • Related Report
      2013 Final Research Report
  • [Journal Article] Plasminogen activator inhibitor-1 is involved in streptozotocin-induced bone loss in female mice.2013

    • Author(s)
      田村行識、河尾直之、岡田 清孝、矢野昌人、奥本勝美、松尾 理、梶 博史
    • Journal Title

      Diabetes

      Volume: 62 Issue: 9 Pages: 3170-3179

    • DOI

      10.2337/db12-1552

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasminogen plays a crucial role in bone repair2013

    • Author(s)
      Kawao N, Tamura Y, Okumoto K, Yano M, Okada K, Matsuo O. Kaji H
    • Journal Title

      J Bone Miner Res

      Volume: 28 Issue: 7 Pages: 1561-1574

    • DOI

      10.1002/jbmr.1921

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enzamin ameliorates adipose tissue inflammation with impaired adipocytokine expression and insulin resistance in db/db mice2013

    • Author(s)
      Tamur a Y, Yano M, Kawao N, Okumoto K, Ueshima S, Kaji H, Matsuo O
    • Journal Title

      J Nutr Sci.

      Volume: 2 Pages: 1-10

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of matrix metalloproteinase-10 in the BMP-2 inducing osteoblastic differentiation2013

    • Author(s)
      Mao L, Yano M, Kawao N, Tamur a Y, Okada K, Kaji H
    • Journal Title

      Endocrine Journal

      Volume: 60 Issue: 12 Pages: 1309-1319

    • DOI

      10.1507/endocrj.EJ13-0270

    • NAID

      130004770406

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production2013

    • Author(s)
      Okada K, Ueshima S, Kawao N, Yano M, Tamura Y, Tanaka M, Sakamoto A, Hatano M, Arima M, Miyata S, Nagai N, Tokuhisa T, and Matsuo O
    • Journal Title

      Life Sci

      Volume: 93 Issue: 2-3 Pages: 89-95

    • DOI

      10.1016/j.lfs.2013.05.023

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antithrombotic effect of taurine inhealthy Japanese people may be related to an increased endogenous thrombolytic activity2013

    • Author(s)
      Yamori Y.
    • Journal Title

      Thrombosis Research

      Volume: 131 Issue: 2 Pages: 158-161

    • DOI

      10.1016/j.thromres.2012.09.021

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ezetimibe Ameliorates Early Diabetic Nephropathy in db/db Mice2012

    • Author(s)
      Tamura, Y., T. Murayama, M. Minami, T. Matsubara, M. Yokode, and H. Arai.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 19 Issue: 7 Pages: 608-618

    • DOI

      10.5551/jat.11312

    • NAID

      130004444616

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Urokinase-type plasminogen activator and plasminogen mediate activation of macrophage phagocytosis during liver repair in vivo.2012

    • Author(s)
      Kawao N, Nagai N, Tamura Y, Horiuchi Y, Okumoto K, Okada K, Suzuki Y, Umemura K, Yano M, Ueshima S, Kaji H, Matsuo O.
    • Journal Title

      Thromb Haemost

      Volume: 107 Issue: 04 Pages: 749-59

    • DOI

      10.1160/th11-08-0567

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Role of plasminogen activator inhibitor-1 in the development of insulin resistance and osteoporosis in obese female mice2014

    • Author(s)
      田村行識
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病病態とビタミンD欠乏状態が骨修復に及ぼす影響の検討2014

    • Author(s)
      田村行識
    • Organizer
      第13回再生医療学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖代謝異常を伴う肥満マウスにおける骨脆弱化の機序について2014

    • Author(s)
      田村行識、河尾直之、矢野昌人、岡田清孝、松尾理、梶博史
    • Organizer
      第57日本糖尿病学会年次学術総会
    • Place of Presentation
      大阪市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肥満に伴うインスリン抵抗性と骨粗鬆症の病態進展におけるプラスミノゲンアクチベーターインヒビター1の役割2014

    • Author(s)
      田村行識、河尾直之、矢野昌人、岡田清孝、松尾理、梶博史
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Plasminogen activator inhibitor-1 contributes to the pathogenesis of diabetic osteoporosis in female mice2013

    • Author(s)
      Tamura Y
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society/Japanese Society of Bone and Mineral Metabolism
    • Place of Presentation
      Kobe
    • Related Report
      2013 Final Research Report
  • [Presentation] プラスミノゲンアクチベーターインヒビター1は糖尿病性骨粗鬆症の病態に関与する2013

    • Author(s)
      田村行識
    • Organizer
      第56回日本糖尿病学会学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] Plasminogen activator inhibitor-1 contributes to the pathogenesis of diabetic osteoporosis in female mice.2013

    • Author(s)
      Yukinori Tamura, Naoyuki Kawao, Kiyotaka Okada, Masato Yano, Katsumi Okumoto, Osamu Matsuo, Hiroshi Kaji
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society/Japanese Society of Bone and Mineral Metabolism
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report
  • [Presentation] プラスミノゲンアクチベーター1は糖尿病性骨粗鬆症の病態に関与する2013

    • Author(s)
      田村行識、河尾直之、岡田清孝、矢野昌人、奥本勝美、松尾理、梶博史
    • Organizer
      第56回日本糖尿病学会年次学術総会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖尿病性骨粗鬆症の病態におけるPlasminogen Activator Inhibitor-1の役割2013

    • Author(s)
      梶博史、田村行識、河尾直之、岡田清孝、矢野昌人、奥本勝美、松尾理
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Plasminogen activator inhibitor-1 is involved in streptozotocin-induced diabetic bone loss in female mice.2012

    • Author(s)
      Yukinori Tamura, Naoyuki Kawao, Kiyotaka Okada, Masato Yano, Katsumi Okumoto, Osamu Matsuo, Hiroshi Kaji
    • Organizer
      American Society of Bone Mineral and Research 2012 annual meeting
    • Place of Presentation
      Minneapolis, Minesota, USA(Minneapolis convention center)
    • Related Report
      2012 Research-status Report
  • [Presentation] Role of plasminogen in bone repair in heterotopic ossification.2012

    • Author(s)
      Naoyuki Kawao, Yukinori Tamura, Katsumi Okumoto, Masato Yano, Kiyotaka Okada Osamu Matsuo, Hiroshi Kaji
    • Organizer
      American Society of Bone Mineral and Research 2012 annual meeting
    • Place of Presentation
      Minneapolis, Minesota, USA(Minneapolis convention center)
    • Related Report
      2012 Research-status Report
  • [Presentation] 糖尿病性骨粗鬆症の病態機序におけるPAI-1の役割2012

    • Author(s)
      田村 行識、松尾 理、梶 博史
    • Organizer
      第105回近畿生理学談話会
    • Place of Presentation
      大阪(関西医科大学)
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.med.kindai.ac.jp/physio2/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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