Role of p62 and Nbr1 in regulation of food intake regulation
| Project/Area Number |
24790232
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | University of Tsukuba |
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Principal Investigator |
WARABI Eiji 筑波大学, 医学医療系, 講師 (70396612)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 摂食調節 / オートファジー / レプチン / p62 / Nbr1 / 細胞増殖 / ネクローシス |
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| Research Abstract |
Though Nbr1 is known to have similar domain structure as p62, the physiological function has been uncovered. In this study, we aimed to examine the Nbr1 function. We used WT and p62-KO mice to establish WT, p62-KO, WT:Nbr2-KD, p62-KO:Nbr1KD MEFs (mouse embryonic fibroblast). We found the cell growth ratio in WT:Nbr1-KD cells are significantly slower than the other cells. Because total- and phosphorylated-p38 levels were decreased, we speculated Nbr1 has a role to regulate p38 protein level, and Nbr1 deficiency results in the decrease in cell growth ratio.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain2013
Author(s)
Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, and Sakurai T．
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Journal Title
J. Neurosci.
Volume: 33
Issue: 37
Pages: 14767-14777
DOI
Related Report
Peer Reviewed
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