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Role of p62 and Nbr1 in regulation of food intake regulation

Research Project

Project/Area Number 24790232
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionUniversity of Tsukuba

Principal Investigator

WARABI Eiji  筑波大学, 医学医療系, 講師 (70396612)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords摂食調節 / オートファジー / レプチン / p62 / Nbr1 / 細胞増殖 / ネクローシス
Research Abstract

Though Nbr1 is known to have similar domain structure as p62, the physiological function has been uncovered. In this study, we aimed to examine the Nbr1 function. We used WT and p62-KO mice to establish WT, p62-KO, WT:Nbr2-KD, p62-KO:Nbr1KD MEFs (mouse embryonic fibroblast). We found the cell growth ratio in WT:Nbr1-KD cells are significantly slower than the other cells. Because total- and phosphorylated-p38 levels were decreased, we speculated Nbr1 has a role to regulate p38 protein level, and Nbr1 deficiency results in the decrease in cell growth ratio.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (16 results)

  • [Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain2013

    • Author(s)
      Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, and Sakurai T.
    • Journal Title

      J. Neurosci.

      Volume: 33 Issue: 37 Pages: 14767-14777

    • DOI

      10.1523/jneurosci.2954-12.2013

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Obesity in p62-KO mice is prevented by estradiol2014

    • Author(s)
      Eiji Warabi, Kentaro Akiyama, Junichi Shoda and Tetsuro Ishii
    • Organizer
      The Environmental Response
    • Place of Presentation
      Sendai
    • Year and Date
      2014-02-28
    • Related Report
      2013 Final Research Report
  • [Presentation] p62/Sqstm1欠損は中枢におけるレプチン抵抗性により過食を引き起こす2013

    • Author(s)
      蕨栄治、石井哲郎、正田純一
    • Organizer
      第8回臨床ストレス応答学会
    • Place of Presentation
      松本
    • Year and Date
      2013-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] p62 : Nrf2遺伝子二重欠損マウスは過食によりNASHを自然発症する2013

    • Author(s)
      蕨栄治、秋山健太郎、正田純一
    • Organizer
      JDDW 2013
    • Place of Presentation
      東京
    • Year and Date
      2013-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] p62 : Nrf2遺伝子二重欠損マウスは脂肪性肝炎を自然発症する2013

    • Author(s)
      秋山健太郎、岡田浩介、正田純一、蕨栄治
    • Organizer
      第68回日本生化学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Interaction of Sequestosome1/p62 with voltage-activated potassium channels in arterial smooth muscle cells in injury-induced arterial remodeling2013

    • Author(s)
      Tetsuro Ishii, Eiji Warabi, Richard C.M. Siow and Giovanni E. Mann
    • Organizer
      IUPS2013
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      2013-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] p62/Sequestosome1欠損によるメタボリックシンドローム発症機序の解析2013

    • Author(s)
      蕨栄治、柳川徹、正田純一
    • Organizer
      第66回日本酸化ストレス学会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-06-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 過食肥満により脂肪性肝炎を自然発症するp62 : Nrf2遺伝子二重欠失マウスの腸管病変とその病態的意義2013

    • Author(s)
      秋山健太郎、正田純一、蕨栄治
    • Organizer
      第49回日本肝臓学会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 過食肥満により脂肪性肝炎を自然発症するp62 : Nrf2遺伝子二重欠失マウスの腸管病変とその病態的意義2013

    • Author(s)
      秋山健太郎、正田純一、蕨栄治
    • Organizer
      第21回肝病態生理研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪性肝炎を自然発症する過食肥満マウスの腸管病変と病態的意義2013

    • Author(s)
      池田瑛、蕨栄治、正田純一
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] p62/Sequestosome1欠損によるメタボリックシンドローム発症機序の解析2013

    • Author(s)
      10. 蕨 栄治、柳川徹、正田純一.
    • Organizer
      第66回日本酸化ストレス学会
    • Place of Presentation
      名古屋 ウインクあいち
    • Related Report
      2013 Annual Research Report
  • [Presentation] p62/Sqstm1欠損は中枢におけるレプチン抵抗性により過食を引き起こす2013

    • Author(s)
      6. 蕨 栄治、石井哲郎、正田純一.
    • Organizer
      第8回臨床ストレス応答学会
    • Place of Presentation
      信州大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nrf2 : p62遺伝子二重欠損マウスは脂肪性肝炎を自然発症し、肝腫瘍を発生する2012

    • Author(s)
      蕨栄治、岡田浩介、正田純一
    • Organizer
      JDDW 2012
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Estradiol prevents obesity formation in Sqstm1/p62-KO mice2012

    • Author(s)
      Eiji Warabi, Airi Ueda, Tetsuro Ishii
    • Organizer
      16^<th> SFRRI Biennial Meeting
    • Place of Presentation
      London, UK
    • Year and Date
      2012-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Nrf2 activation remarkably improves exercise endurance capacity in mice2012

    • Author(s)
      Sechang Oh, Eiji Warabi, Masayuki Yamamoto, Kiyoji Tanaka, Junichi Shoda
    • Organizer
      16^<th> SFRRI Biennial Meeting
    • Place of Presentation
      London, UK
    • Year and Date
      2012-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Nrf2/p62遺伝子二重欠損マウスは脂肪性肝炎を自然発症し、肝腫瘍を発生する2012

    • Author(s)
      蕨栄治、岡田浩介、徳重克年、橋本悦子、正田純一
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Nrf2/p62遺伝子二重欠損マウスは脂肪性肝炎を自然発症し、肝腫瘍を発生する2012

    • Author(s)
      蕨栄治、岡田浩介、徳重克年、橋本悦子、正田純一
    • Organizer
      第20回肝病態生理研究会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-06
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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