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Brown adipose differentiation by in vivo optogenetic stimulation

Research Project

Project/Area Number 24790233
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKyoto University

Principal Investigator

KATAOKA Naoya  京都大学, 生命科学系キャリアパス形成ユニット, 研究員 (20572423)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords褐色脂肪組織 / 誘導型褐色脂肪組織 / 光遺伝学 / 交感神経プレモーターニューロン / 延髄縫線核 / 光遺伝学的手法 / エネルギー代謝 / 肥満 / 交感神経 / brite cell / 誘導型褐色脂肪細胞 / 非ふるえ熱産生
Outline of Final Research Achievements

In the central regulation of thermogenesis in brown adipose tissue (BAT), sympathetic premotor neurons in the rostral raphe pallidus nucleus (rRPa). Brown adipose, which expresses the thermogenic protein UCP1, provides a defense against cold and obesity, not only in rodents but even in adult humans. Moreover, the appearance of brown-like adipocytes within white adipose tissue depots is associated with improved metabolic phenotypes. In this study, using an optogenetic technique, we examined whether the sympathetic outflow could cause the differentiation of brite cell into the subcutaneous fat. Adeno associated virus (AAV)-mediated delivery of ChIEF gene into rat rRPa resulted in localization of ChIEF proteins in the rRPa neurons. In vivo photostimulation of ChIEF-expressing cell bodies in the rRPa elicited increases in BAT thermogenesis, blood pressure and heart rate.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (11 results) (of which Invited: 1 results)

  • [Journal Article] Psychological Stress Activates a Dorsomedial Hypothalamus-Medullary Raphe Circuit Driving Brown Adipose Tissue Thermogenesis and Hyperthermia.2014

    • Author(s)
      Kataoka N, Hioki H, Kaneko T, Nakamura K.
    • Journal Title

      Cell Metab

      Volume: 20(2) Issue: 2 Pages: 346-358

    • DOI

      10.1016/j.cmet.2014.05.018

    • NAID

      120005553940

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Search of the limbic and cortical regions involved in psychological stress-induced hyperthermia2015

    • Author(s)
      片岡直也
    • Organizer
      第92回 日本生理学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sociopsychological stress activates hypothalamo-medullary neurons that drive brown adipose tissue thermogenesis and hyperthermia2014

    • Author(s)
      片岡直也
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] A direct hypothalamo-medullary pathway for sociopsychological stress-induced brown fat thermogenesis and hyperthermia2014

    • Author(s)
      片岡直也
    • Organizer
      第91回 日本生理学会大会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Sociopsychological stress activates hypothalamo-medullary neurons that drive brown adipose tissue thermogenesis and hyperthermia2014

    • Author(s)
      片岡直也
    • Organizer
      Experimental Boplogy 2014
    • Place of Presentation
      San Diego
    • Related Report
      2013 Research-status Report
  • [Presentation] Direct projection from the dorsomedial hypothalamus to the rostral medullary raphe drives brown adipose tissue thermogenesis2013

    • Author(s)
      片岡直也
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston (USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] 視床下部背内側部から吻側延髄縫線核への興奮性の直接入力は褐色脂肪熱産生を惹起する2013

    • Author(s)
      片岡直也
    • Organizer
      第18回 アディポサイエンスシンポジウム
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] 視床下部背内側部から吻側延髄縫線核への興奮性の直接入力は社会的敗北ストレスによる褐色脂肪熱産生を惹起する2013

    • Author(s)
      片岡直也
    • Organizer
      平成25年度 温熱生理研究会
    • Place of Presentation
      生理学研究所
    • Related Report
      2013 Research-status Report
  • [Presentation] 視床下部背内側部から延髄縫線核への興奮性入力は褐色脂肪熱産生を惹起する2013

    • Author(s)
      片岡直也
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] Social defeat stress-induced hyperthermia involves non-shivering thermogenesis in brown adipose tissue2012

    • Author(s)
      片岡直也
    • Organizer
      Experimental Biology 2012
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] 社会的敗北ストレスによる高体温は延髄縫線核を介した褐色脂肪熱産生が寄与する2012

    • Author(s)
      片岡直也
    • Organizer
      平成24年度 温熱生理研究会
    • Place of Presentation
      生理学研究所
    • Related Report
      2012 Research-status Report
  • [Presentation] Social defeat stress-induced hyperthermia involves non-shivering thermogenesis in brown adipose tissue2012

    • Author(s)
      片岡直也
    • Organizer
      第35回 日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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