Polyunsaturated fatty acids: role as a mediator in learning and memory
Project/Area Number |
24790234
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
Research Institution | Shimane University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 多価不飽和脂肪酸 / 神経新生 / ドコサヘキサエン酸 / エイコサペンタエン酸 / 遊離脂肪酸受容体 / fatty acid / docosahexaenoic acid / neurogenesis / docosanoids / 神経幹細胞 / Gタンパク質共役型受容体 |
Research Abstract |
Polyunsaturated fatty acids are essential for the growth and functional development of the brain. The present study aimed to examine the role of polyunsaturated fatty acids as mediator on the learning and memory functions. Omega-3 polyunsaturated fatty acids improve learning memory by increasing brain-derived neurotrophic factor and docosahexaenoic acid-derived metabolites in the hippocampus. Docosahexaenoic acid and eicosapentaenoic acid could be induced neuronal differentiation of cultured neural stem cells via different mechanisms. Free fatty acid-activated G protein-coupled receptor 40 activation enhanced neuronal and glial differentiation. These results indicate that Omega-3 polyunsaturated fatty acids could be involved to improve learning and memory functions via neurogenesis.
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Report
(3 results)
Research Products
(50 results)