An interpretation study of a mechanisms to acquire the neural correlates of maternal parenting behaviors in humans and its endocrine and genetic regulations

• Project/Area Number: 24790235
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Nagasaki University
• Principal Investigator: NISHITANI Shota 長崎大学, 医歯(薬)学総合研究科, 助教 (50448495)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 母性 / エピジェネティックス / ホルモン / メチル化 / OXTR / 遺伝子 / NIRS / 前頭前野 / 発達・成長・老化 / 脳

Research Abstract

We investigated whether DNA methylations in the promoter region of the oxytocin receptor (OXTR) gene predict the neural activations linked with maternal parenting behaviors, and whether the methylation statuses are related to a mechanism to acquire the neural correlates of maternal parenting behaviors. We measured DNA methylations from saliva-extracted DNA by means of pyrosequencing in 38 mothers who were participated in our previous study which focused on the neural activation of the anterior part of the prefrontal cortex (APFC) during seeing their own infants' facial expressions against other unfamiliar infants' facial expressions measured by near infrared spectroscopy (NIRS). We found that there was a significant correlation between the methylation rate of a specific CpG site and the activation of the right inferior part of the APFC. These results suggest that the methylation status in the promoter region predicts the neural activations linked with maternal parenting behaviors.

Research Products

• [Journal Article] Maternal prefrontal cortex activation by newborn infant odors (2014)
  • Author(s): Nishitani S, Kuwamoto S, Takahira A, Miyamura T, Shinohara K
  • Journal Title: Chem Senses Volume: 39 (3) Pages: 195-202
• [Journal Article] 特集「家族関係の行動神経基盤」家族「愛」の神経基盤 (2013)
  • Author(s): 西谷正太,木田哲夫,高村恒人,篠原一之
  • Journal Title: 分子精神医学(先端医学社) Volume: 13(4)
• [Journal Article] No association between catechol-o-methyltransferase (COMT) genotype and attention deficit hyperactivity disorder (ADHD) in Japanese children (2013)
  • Author(s): Yatsuga C, Toyohisa D, Fujisawa TX, Nishitani S, Shinohara K, Matsuura N, Ikeda S, Muramatsu M, Hamada A, Tomoda A
  • Journal Title: Brain & Dev. Volume: S0387-7604 (13) Pages: 258-1
• [Journal Article] No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents (2013)
  • Author(s): Tomoda A, Nishitani S, Matsuura N, Fujisawa TX, Kawatani J, Toyohisa T, Ono M, Shinohara K
  • Journal Title: BMC Psychiatry Volume: 10;13 Pages: 134-134
  • NAID: 120006985859
• [Journal Article] Phosphorylation of cAMP response element-binding protein in the extended amygdala of male rats is induced by novel environment and attenuated by estrus female-bedding (2013)
  • Author(s): Nishitani S, Funabashi T, Shinohara K, Kimura F
  • Journal Title: Neuro Endocrinol Lett Volume: 34(2) Pages: 118-23
• [Journal Article] Prenatal exposure to polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old : a preliminary study (2013)
  • Author(s): Doi H, Nishitani S, Fujisawa TX, Nagai T, Kakeyama M, Maeda T, Shinohara K
  • Journal Title: PLoS ONE Volume: 8(3)
  • NAID: 120006985955
• [Journal Article] 嗅覚 : フェロモンなどの匂いを介したコミュニケーション (2013)
  • Author(s): 篠原一之,西谷正太
  • Journal Title: 日本香粧品学会誌 Volume: 36(4) Pages: 303-9
  • NAID: 130004647032
• [Journal Article] 思春期の社会性発達にもたらす性腺ホルモンの影響 (2013)
  • Author(s): 藤澤隆史,西谷正太,篠原一之
  • Journal Title: 思春期学 Volume: Vol.31 (1) Pages: 91-92
• [Journal Article] 思春期における愛着に関わる脳機能発達 (2013)
  • Author(s): 高村恒人,西谷正太,篠原一之
  • Journal Title: 思春期学 Volume: 31 (1) Pages: 87-88
• [Journal Article] NIRS as a tool for assaying emotional function in the prefrontal cortex (2013)
  • Author(s): Doi H, Nishitani S, Shinohara K
  • Journal Title: Front Hum Neurosci Volume: 7 Pages: 770-770
  • NAID: 120006986018
  • Peer Reviewed
• [Journal Article] 特集「家族関係の行動神経基盤」 家族「愛」の神経基盤 (2013)
  • Author(s): 西谷正太, 木田哲夫, 高村恒人, 篠原一之
  • Journal Title: 分子精神医学（先端医学社） Volume: 13(4) Pages: 236-242
• [Journal Article] 嗅覚：フェロモンなどの匂いを介したコミュニケーション (2012)
  • Author(s): 篠原一之、西谷正太
  • Journal Title: 日本香粧品学会誌 Volume: 36(4) Pages: 303-9
  • NAID: 130004647032
• [Journal Article] 成人愛着スタイルにおける遺伝・環境要因の検討 (2012)
  • Author(s): 谷口弘一、西谷正太
  • Journal Title: 日本発達心理学会大会論文集 Volume: 23 Pages: 658-658
• [Journal Article] NIRS as a tool for assaying emotional function in the prefrontal cortex
  • Author(s): Doi H, Nishitani S, Shinohara K
  • Journal Title: F ront Hum Neurosci Volume: (in press)
  • NAID: 120006986018
• [Journal Article] I love my grandkid! An NIRS study of grandmaternal love
  • Author(s): Kida T, Nishitani S, Tanaka M, Takamura T, Sugawara M, Shinohara K
  • Journal Title: Brain Res Volume: (in press)
• [Presentation] Neural correlates of maternal love, paternal love, and children's love for their parents (2013)
  • Author(s): Shinohara K, Nishitani S(代理発表者), Takamura T
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] 周産期から育まれる母性脳～脳科学から見た獲得メカニズム～ (2013)
  • Author(s): 西谷正太
  • Organizer: 日本妊産婦支援協議会りんごの木
  • Place of Presentation: 大阪
• [Presentation] 母性愛、父性愛、子の愛着の神経相関
  • Author(s): 篠原一之、西谷正太、高村恒人
  • Organizer: 第90回日本生理学会
  • Place of Presentation: 東京
• [Presentation] OXTR、AVPR1A遺伝子多型による我が子の笑顔呈示に対する母親、父親の前頭前野活動の修飾
  • Author(s): 西谷正太、池松和哉、高村恒人、本田純久、吉浦孝一郎、篠原一之
  • Organizer: 第90回日本生理学会
  • Place of Presentation: 東京
• [Remarks]
  • URL: http://www.med.nagasaki-u.ac.jp/physlgy2/index.html
• [Patent(Industrial Property Rights)] エストロジェン分泌増進用組成物、及びその芳香組成物、並びにその芳香用具 (2013)
  • Inventor(s): 篠原一之,土居裕和,西谷正太
  • Industrial Property Rights Holder: 株式会社マザー&チャイルド
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-08-10
• [Patent(Industrial Property Rights)] エストロジェン及びテストステロン分泌増進用組成物、及びその芳香組成物、並びにその芳香用具 (2013)
  • Inventor(s): 篠原一之,土居裕和,西谷正太
  • Industrial Property Rights Holder: 株式会社マザー&チャイルド
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-08-10
• [Patent(Industrial Property Rights)] エストロジェン分泌増進用組成物、及びその芳香組成物、並びにその芳香用具 (2013)
  • Inventor(s): 篠原一之, 土居裕和, 西谷正太
  • Industrial Property Rights Holder: 株式会社マザー＆チャイルド
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-08-09
• [Patent(Industrial Property Rights)] エストロジェン及びテストステロン分泌増進用組成物、及びその芳香組成物、並びにその芳香用具 (2013)
  • Inventor(s): 篠原一之, 土居裕和, 西谷正太
  • Industrial Property Rights Holder: 株式会社マザー＆チャイルド
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-08-09
• [Patent(Industrial Property Rights)] プロジェステロンの変化に伴う不快症状の改善用組成物、及びその芳香治療用組成物、並びにその芳香治療用具 (2012)
  • Inventor(s): 篠原一之,諸伏雅代,西谷正太,牧野内俊治
  • Industrial Property Rights Holder: 株式会社マザー&チャイルド
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2012-10-26