Roles of secretin-oxytocin system in the control of social recognition/ memory.
| Project/Area Number |
24790236
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | オキシトシン / セクレチン / 社会的記憶 / 視索上核 / 内側扁桃体 |
|---|
| Research Abstract |
Secretin activated oxytocin neurons of the supraoptic nucleus and facilitated oxytocin release centrally. Local application of secretin into the supraoptic nucleus facilitated social recognition/ memory. The facilitative effects of secretin upon social recognition/ memory were inhibited by an oxytocin receptor antagonist injected into the medial amygdala or in oxytocin receptor-deficient mice. Furthermore, oxytocin treatment restored social recognition/ memory in secretin receptor-deficient mice. All these results suggest that newly defined secretin-oxytocin system plays a critical role in regulating social memory/ recognition.
|
Report
(3 results)
Research Products
(20 results)
-
-
-
[Journal Article] Oxytocin Receptor in the Hypothalamus Is Sufficient to Rescue Normal Thermoregulatory Function in Male Oxytocin Receptor Knockout Mice.2013
Author(s)
Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So K-H, Kawada T, Inoue N, Ikeda I, Roh S-G, Itoi K, and Nishimori
-
Journal Title
Endocrinology
Volume: 154
Issue: 11
Pages: 4305-4315
DOI
Related Report
Peer Reviewed
-
[Journal Article] Involvement of prolactin-releasing peptide in the activation of oxytocin neurones in response to food intake.2013
Author(s)
Yamashita,M., Takayanagi,Y., Yoshida,M., Nishimori,K., Kusama, M. and Onaka,T.
-
Journal Title
Journal of Neuroendocrinology
Volume: 25
Issue: 5
Pages: 455-465
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
