| Project/Area Number |
24790243
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Research Collaborator |
UETA Yoichi 産業医科大学, 医学部, 教授 (10232745)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | サーカディアンリズム / バゾプレッシン / 視交叉上核 / GABA / バソプレッシン / 生体リズム / 環境生理学 |
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| Research Abstract |
Arginine vasopressin (AVP) is well known as a peptide concern to adjust body fluid and blood pressure. AVP neuron is also located in the dorsomedial parts of the suprachiasmatic nucleus (SCN) which is the central circadian rhythm generator and considered to have some role in generating circadian rhythm. We used the AVP-eGFP transgenic rat and investigated the electrophysiological property of AVP neuron in the SCN. Our study showed that AVP neurons response to GABA are different in case of dissociated time. It is possible that AVP neuron in the SCN has a electrophysiological circadian rhythm that depends on intracellular chloride ion concentration.
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