Role of the prostanoid in cisplatin-induced nephropathy
| Project/Area Number |
24790246
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kitasato University (2014)
Asahikawa Medical College (2012-2013) |
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Principal Investigator |
KOJIMA Fumiaki 北里大学, 医療衛生学部, 准教授 (30550545)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | プロスタノイド |
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| Outline of Final Research Achievements |
We investigated the role of the EP1 receptor (a prostaglandin (PG) E2 receptor subtype) in the cisplatin-induced acute kidney injury using EP1 knock-out (KO) mice. Three days following cisplatin injection, nephrotoxicity biomarkers including plasma creatinine, blood urea nitrogen (BUN) and kidney injury molecule-1 (Kim-1) were significantly increased in wild-type (WT) mice, while these changes were diminished in EP1 KO mice. Histopathological analyses further showed a significant reduction in structural damages in EP1 KO kidney compared to WT kidney after cisplatin injection. In addition, the improvements of functional and structural abnormalities consistent with nephrotoxicity observed in EP1 KO mice were associated with significantly lower levels of renal inflammatory cytokine expression and oxidative stress. These results indicate that PGE2-EP1 system plays a crucial role in cisplatin-induced nephrotoxicity.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice.2012
Author(s)
Nakagawa N, Yuhki K, Kawabe J, Fujino T, Takahata O, Kabara M, Abe K, Kojima F, Kashiwagi H, Hasebe N, Kikuchi K, Sugimoto Y, Narumiya S, Ushikubi F.
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Journal Title
Kidney Int.
Volume: 82
Pages: 158-171
Related Report
Peer Reviewed
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