| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
To understand the relationship between the change of Cx43 expression and the regulation of nociceptive responses under neuropathic pain, the current study utilized partial sciatic nerve ligation (PSNL) model, which mimics some of the major features observed in clinical neuropathic pain. It was found that the expression of Cx43 in spinal dorsal horn following PSNL was significantly decreased during the maintenance phase, but not the induction phase of neuropathic pain, and this response was mediated by tumor necrosis factor (TNF)-c-jun N-terminal kinase (JNK)-dependent pathway. Furthermore, the decrease of Cx43 expression could be related in the induction of mechanical hypersensitivity.
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