The role of astroglial gap juncton in the regulation of chronic pain
| Project/Area Number |
24790253
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 疼痛 / アストロサイト / gap junction / connexin43 / 脊髄アストロサイト / 神経因性疼痛 / TNF / IFN-γ / proteasome / 慢性疼痛 / TNF-α |
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| Research Abstract |
To understand the relationship between the change of Cx43 expression and the regulation of nociceptive responses under neuropathic pain, the current study utilized partial sciatic nerve ligation (PSNL) model, which mimics some of the major features observed in clinical neuropathic pain. It was found that the expression of Cx43 in spinal dorsal horn following PSNL was significantly decreased during the maintenance phase, but not the induction phase of neuropathic pain, and this response was mediated by tumor necrosis factor (TNF)-c-jun N-terminal kinase (JNK)-dependent pathway. Furthermore, the decrease of Cx43 expression could be related in the induction of mechanical hypersensitivity.
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Report
(3 results)
Research Products
(12 results)
