The role of cyclophilin A in diabetic vascular calcification
| Project/Area Number |
24790254
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ISHIZAWA Yuki 徳島大学, ヘルスバイオサイエンス研究部, 助教 (40610192)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 心血管・血液 / 糖尿病 / 血管石灰化 / 酸化ストレス / 薬理学 / サイクロフィリンA / Rho-kinase |
|---|
| Research Abstract |
Arterial calcification is accompanied by several cardiovascular diseases such as atherosclerosis, diabetes mellitus, and renal failure. Osteogenic differentiation of vascular smooth muscle cell (VSMC) plays important role in vascular calcification. It was observed that the inorganic phosphate (Pi) increased rho-kinase activation which is reported to be involved in the autocrine of cyclophilin A, alkaline phosphatase (ALP) activity, and calcium accumulation in cultured VSMCs. The pretreatment with rho-kinase inhibitor inhibited Pi-induced ALP activity and calcium accumulation. From these results, it was suggested that rho-kinase activation and the autocrine of cyclophilin A might be related with Pi-induced vascular calcification.
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Report
(3 results)
Research Products
(57 results)
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[Journal Article] Deletion of Hypoxia-Inducible Factor-1α in Adipocytes Enhances Glucagon-Like Peptide-1 Secretion and Reduces Adipose Tissue Inflammation2014
Author(s)
Yoshitaka KIHIRA, Mariko MIYAKE, Manami HIRATA, Yoji HOSHINA, Kana KATO, Hitoshi SHIRAKAWA, Hiroshi SAKAUE, Noriko YAMANO, Yuki IZAWA-ISHIZAWA, Keisuke ISHIZAWA, Yasumasa IKEDA, Koichiro TSUCHIYA, Toshiaki TAMAKI, Shuhei TOMITA
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Journal Title
PLOS ONE
Volume: 9
Issue: 4
Pages: e93856-e93856
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction.2014
Author(s)
Ikeda Y, Ozono I, Tajima S, Imao M, Horinouchi Y, Izawa-Ishizawa Y, Kihira Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T.
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Journal Title
PLoS One.
Volume: 9
Issue: 2
Pages: e89355-e89355
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nitrosonifedipine ameliorates the progression of type 2 diabetic nephropathy by exerting antioxidative effects.2014
Author(s)
Ishizawa K, Izawa-Ishizawa Y, Yamano N, Urushihara M, Sakurada T, Imanishi M, Fujii S, Nuno A, Miyamoto L, Kihira Y, Ikeda Y, Kagami S, Kobori H, Tsuchiya K, Tamaki T.
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Journal Title
PLoS One.
Volume: 9(1)
Issue: 1
Pages: 86335-86335
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Anti-inflammatory effects of statins and anti-malarial agents via endothelial ERK5 activation2014
Author(s)
Yuki Izawa-Ishizawa, Nhat-Tu Le, Yuichiro Takei, Kyung-Sun Heo, Hakjoo Lee, Alan Smrcka, Benjamin Miller, Kyung-Ae Ko, Sara Ture, Craig Morrell, Keigi Fujiwara, Masashi Akaike, Toshiaki Tamaki, Jun-ichi Abe
Organizer
第87回日本薬理学会年会
Place of Presentation
仙台国際センター（ 宮城県）
Related Report
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[Presentation] A HMG-CoA Reductase Inhibitor (statin) Directly Activates Endothelial Erk5 And Prevents Endothelial Dysfunction And Acute Cardiac Allograft Rejection2013
Author(s)
Nhat-Tu Le, Yuichiro Takei, Yuki Izawa-Ishizawa, Kyung-Sun Heo, Hakjoo Lee, Alan V. Smrcka, Benjamin Miller, Kyung Ae Ko, Craig Morrell, Keigi Fujiwara, Masashi Akaike and Jun-ichi Abe
Organizer
AHA scientific sessions 2013
Place of Presentation
Dallas Convention Center (アメリカ)
Related Report
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