| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In vasopressin V1a receptor deficient mice, we observed the decrease of the number of birth, delay of the initiation of parturition, and the prolongation of the duration of labor. These changes were dependent on the maternal genetic background of mice, rather than paternal or fetal genetic background. We also revealed by in situ hybridization analyzes with male reproductive organs that there were intense V1a receptor expressions in bladder, testis, vas deference and epididymis, most of which were interstitial tissue. In female reproductive organs, V1a receptor was also observed in ovary and uterus. These results suggest that V1a receptor has important roles in male and female reproductive physiology and could provide important information in the elucidation of the pathophysiology associated with vasopressin.
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