| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
This study suggested that the candidate mediator for endothelium-deriverd hyperpolarizing factor (EDHF) in retinal blood vessels may be epoxyeicosatrienoic acid. Moreover, in retinal blood vessels, gap junction has been played a key role in EDHF-mediated vasodilation. Furthermore, our study suggested that increased oxidative stress, such as 4-hydroxy-2-nonenal, in retinal blood vessels and retinal neuronal cells of diabetes and glaucoma rats may be an important mechanism responsible for impairment of the vasodilator mechanisms in retinal blood vessels. In conclusion, potent antioxidative drugs may be novel candidates for prevention and/or treatment of glaucoma and diabetic retinopathy.
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