Control mechanism of hydrogen sulfide producing enzyme by phosphorylation
| Project/Area Number |
24790263
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 含硫アミノ酸代謝酵素 / リン酸化修飾 / 翻訳後修飾 / 硫化水素関連酵素 |
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| Research Abstract |
We investigated control mechanism of sulfur-containing amino acid metabolic enzyme, cystathionine beta-synthase (CBS), cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase by phosphorylation. We found that CBS is phosphorylated by protein kinases. These data indicate that CBS might be controlled by its phosphorylation.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling2014
Author(s)
Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: (印刷中)
Pages: 7606-7611
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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