| Project/Area Number |
24790272
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Chiba University |
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Principal Investigator |
ITO Takashi 千葉大学, 医学部附属病院, 特任助教 (20597124)
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| Research Collaborator |
MINAMINO Tohru 新潟大学, 医歯学総合研究科, 教授 (90328063)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 慢性炎症 / 細胞老化 / 血管内皮細胞 / CDC42 / 動脈硬化 / 寿命 / 老化 / PAK2 / 個体老化 |
|---|
| Research Abstract |
Chronic inflammation underlies most age-related diseases such as cancer, cardiovascular disease, and neurodegenerative disorder. This research focuses on a phenomenon called cellular senescence, in which multiple genes associated with inflammation are upregulated. We identified CDC42 as a regulator of inflammatory genes in senescent vascular cells, and also as a regulator of atherosclerosis in mice. CDC42 was the cause of short lifespan of mutant worms with immune over activation, a model for chronic inflammation of mammals. These results suggest that CDC42 has a critical role in chronic inflammation and age-related diseases.
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