Molecular analysis of TMEM16 family members
| Project/Area Number |
24790278
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
SUZUKI Jun 京都大学, 医学(系)研究科(研究院), 助教 (30511894)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | TMEM16F / TMEM16 / Xkr8 / Xkr / Scramblase / リン脂質スクランブリング / ホスファチジルセリン / アポトーシス / リン脂質 / スクランブル活性 / クロライドチャネル / phosphatidylserine / phophatidylcholine / phosphatidylcholine / galactosylceramide |
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| Outline of Final Research Achievements |
Phospholipids are asymmetrically distributed in plasma membrans. However, its distribution is disrupted by phospholipid scramblases, which transport lipids bidirectionally and nonspecifically. In this study, I investigated molecular functions of TMEM16 family members, and found that TMEM16C, D, F, G, and J possessed phospholipid scrambling activity.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Phospholipid Flippase Activities and Substrate Specificities of Human Type IV P-type ATPases Localized to the Plasma Membrane2014
Author(s)
Takatsu, H., Tanaka, G., Segawa, K., Suzuki, J., Nagata, S., Nakayama, K. and Shin, H.W.
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Journal Title
J. Biol. Chem
Volume: 289
Issue: 48
Pages: 33543-33556
DOI
NAID
Related Report
Peer Reviewed / Open Access
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