Mechanism of the formation of cell-cell adhesion by a peripheral membrane protein afadin
| Project/Area Number |
24790283
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Shiga University of Medical Science (2014)
Kobe University (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞間接着 / アファディン |
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| Outline of Final Research Achievements |
We investigated the roles of the interactions among peripheral membrane proteins that bind to cell-cell adhesion molecules in the formation of cell-cell adhesion and obtained the results, as follows: A novel interaction between afadin and PLEKHA7, which associate with cell adhesion molecules nectin and cadherin, respectively, is critical for the proper formation of adherens junctions in epithelial cells. We identified an α-catenin-binding region of afadin. A short isoform of afadin, s-afadin, which is expressed mainly in the nervous system, binds more preferentially to nectins as compared to afadin.
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Report
(4 results)
Research Products
(4 results)
