Regulation by Nectin-like molecules of hemidesmosome disassembly and reorganization
| Project/Area Number |
24790284
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
MIZUTANI Kiyohito 神戸大学, 医学(系)研究科(研究院), 講師 (50559177)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | ヘミデスモソーム / インテグリン / Necl / Necl-4 / CADM4 / ErbB3 / PTPN13 / 血管内皮細胞 |
|---|
| Outline of Final Research Achievements |
Hemidesmosomes are one of the cell-extracellular matrix junctions. However, the molecular mechanisms that regulate disassembly and reorganization of hemidesmosomes still remain unclear. In this study, we found that 1) Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly and 2) Necl-4 serves as a regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13.
|
Report
(4 results)
Research Products
(14 results)
-
-
-
-
[Journal Article] Absence of primary cilia in cell cycle-arrested human breast cancer cells.2014
Author(s)
Nobutani K, Shimono Y, Yoshida M, Mizutani K, Minami A, Kono S, Mukohara T, Yamasaki T, Itoh T, Takao S, Minami H, Azuma T, Takai Y.
-
Journal Title
Genes Cells.
Volume: 19
Issue: 2
Pages: 141-152
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
