| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
An endocytic receptor, megalin, absorbs functionally and structurally distinct many proteins in the epithelial cells of the kidney with being regulated by adaptor proteins. In the present study, we identified two novel adaptor proteins to regulate the endocytic activity of megalin and revealed the subcellular localization and the physiological function of the adaptor proteins. Our results suggest that one regulates the rate of transportation of megalin from apical membrane to early endosome, and another regulates the recycling of megalin from recycling endosome to apical membrane in the epithelial cells.
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