The role of phosphoinositide metabolism in the interaction of different cell types in skin and tumor
| Project/Area Number |
24790295
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ホスホリパーゼC / 皮膚 |
|---|
| Research Abstract |
The interaction of different cell types is important in the maintenance of skin functions. We found that epidermal loss of phospholipase c (PLC) delta1 upregulated interleukin-23 and generated partially similar environment to tumor microenvironment. We also found that subcutaneous injection of B16-F10 cells into keratinocyte-specific PLC delta1 knockout mice enhanced the growth and metastasis of B16-F10 cells.
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Report
(3 results)
Research Products
(41 results)
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[Journal Article] Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy2014
Author(s)
Nakamura, Y., Kanemaru, K., Kojima, R., Hashimoto, Y., Marunouchi, T., Oka, N., Ogura, T., Tanonaka, K., and Fukami, K
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Journal Title
Related Report
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[Journal Article] Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice2013
Author(s)
Staats, KA., Van, H. L., Jones, A. R., Bento, A. A., Van, H. A., Shatunov, A., Simpson. C.L., Lemmens. R., Jaspers. T., Fukami, K., Nakamura, Y., Brown, RH. Jr., Van, D. P., Liston, A., Robberecht, W., Al-Chalabi. A., and Van, D. B.L
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Journal Title
Neurobiol. Dis
Volume: 60
Pages: 11-7
Related Report
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[Journal Article] Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice.2013
Author(s)
1. Staats, KA., Van, H. L., Jones, A. R., Bento, A. A., Van, H. A., Shatunov, A., Simpson. C.L., Lemmens. R., Jaspers. T., Fukami, K., Nakamura, Y., Brown, RH. Jr, Van, D. P., Liston, A., Robberecht, W., Al-Chalabi. A., and Van, D. B.L.
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Journal Title
Neurobiol. Dis.
Volume: 60
Pages: 11-17
DOI
Related Report
Peer Reviewed
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[Journal Article] Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin 17 levels in mice2012
Author(s)
Kanemaru, K., Nakamura Y., Sato, K., Kojima, R., Takahashi, S., Yamaguchi, M., Ichinohe, M., Kiyonari, H., Shioi, G., Kabashima, K., Nakahigashi, K., Asargiri, M., Jamora, C., Yamaguchi, H., and Fukami, K
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Journal Title
Nat. Commun (1st authors and corresponding authors)
Volume: 963
Related Report
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