| Project/Area Number |
24790296
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Toho University |
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Principal Investigator |
ITO Masanori 東邦大学, 医学部, 講師 (20459811)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 脂質転移タンパク質 / 脂質代謝 / 胆汁酸 / コレステロール / トリグリセリド / 脂肪酸 / 肝臓 / 腸肝循環 / ホスファチジルコリン / 脂質 / lipid droplet / miRNA / エキソソーム |
|---|
| Outline of Final Research Achievements |
STARD10, a member of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) protein family, is highly expressed in the liver and has been shown to transfer phosphatidylcholine. To help elucidate the physiological role of STARD10, we produced Stard10 knockout mice (Stard10－/－) and studied their phenotype. The wet weight of the liver of Stard10-/- mice fed high fat diet was significantly lower than that of wild type mice. The relative contents of cholesterol and triglyceride in the liver were lower in Stard10-/- mice than in wild type mice. Interestingly, PPARα-dependent genes responsible for the regulation of bile acid metabolism were down-regulated in the liver of Stard10－/－ mice. The loss of STARD10 impaired the PPARα activity in mouse hepatoma cells. These results indicate that STARD10 is involved in regulating lipid metabolism through the modulation of PPARα-mediated mechanism.
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