Analysis of JunB function on blood vessel formation in neuro-vascular interactions.
| Project/Area Number |
24790297
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 血管新生 / 神経血管相互作用 / JunB / 神経ー血管相互作用 / 神経-血管相互作用 / 血管ネットワーク形成 |
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| Outline of Final Research Achievements |
In this study, we focused on the genes activated in endothelial cells by interacting with neurons during vascular development and neuro-vascular juxtapositional alignment. We found JunB as a new angiogenic regulator activated in neuro-vascular interactions. JunB regulated endothelial cell shape and tip cell production, and promotes angiogenesis in vivo. In vivo JunB knockdown in endothelial cells decreased branches of parallel aligned with neurons, indicates JunB expression in endothelial cells is required for neuro-vascular juxtapositional alignment. This study will facilitate a better understanding of mechanisms of neuro-vascular alignment and be useful for application studies for the vascular diseases.
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Report
(5 results)
Research Products
(12 results)
