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Analysis of JunB function on blood vessel formation in neuro-vascular interactions.

Research Project

Project/Area Number 24790297
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionKanazawa Medical University

Principal Investigator

YOSHITOMI Yasuo  金沢医科大学, 医学部, 助教 (80399039)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords血管新生 / 神経血管相互作用 / JunB / 神経ー血管相互作用 / 神経-血管相互作用 / 血管ネットワーク形成
Outline of Final Research Achievements

In this study, we focused on the genes activated in endothelial cells by interacting with neurons during vascular development and neuro-vascular juxtapositional alignment. We found JunB as a new angiogenic regulator activated in neuro-vascular interactions. JunB regulated endothelial cell shape and tip cell production, and promotes angiogenesis in vivo. In vivo JunB knockdown in endothelial cells decreased branches of parallel aligned with neurons, indicates JunB expression in endothelial cells is required for neuro-vascular juxtapositional alignment. This study will facilitate a better understanding of mechanisms of neuro-vascular alignment and be useful for application studies for the vascular diseases.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (9 results)

  • [Journal Article] Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation.2016

    • Author(s)
      Ikeda T, Yoshitomi Y, Saito H, Shimasaki T, Yamaya H, Kobata T, Ishigaki Y, Tomosugi N, Yoshitake Y, Yonekura H.
    • Journal Title

      Mol. Cell. Biochem.

      Volume: 413 Issue: 1-2 Pages: 155-164

    • DOI

      10.1007/s11010-015-2649-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia.2015

    • Author(s)
      S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto
    • Journal Title

      Med Mol Morphol.

      Volume: 48 Issue: 2 Pages: 69-75

    • DOI

      10.1007/s00795-014-0077-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epiprofin orchestrates epidermal keratinocyte proliferation and differentiation.2014

    • Author(s)
      Nakamura, T., Yoshitomi, Y., Patel, V., Fukumoto, S., and Yamada, Y.
    • Journal Title

      Journal of cell science

      Volume: 127(24) Pages: 5261-5272

    • DOI

      10.1242/jcs.156778

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 神経-血管相互作用により血管内皮細胞で活性化されるJunBの役割2015

    • Author(s)
      吉冨泰央、池田崇之、吉竹佳の、米倉秀人
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Roles of JunB in the blood vessel network formation during neuro-vascular interactions2014

    • Author(s)
      Yasuo Yoshitomi, Takayuki Ikeda, Yoshino Yoshitake and Hideto Yonekura
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 転移能の異なるルイス肺がん細胞株が形成する腫瘍中に誘導される血管の構造の差異の解明2013

    • Author(s)
      吉冨泰央、池田崇之、吉竹佳の、岡山實、小栗佳代子、米倉秀人
    • Organizer
      第86回 日本生化学会大会
    • Place of Presentation
      横浜市 パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 神経ー血管相互作用を介した血管ネットワーク形成におけるJunBの機能2013

    • Author(s)
      吉冨泰央、池田崇之、吉竹佳の、八田稔久、加藤伸郎、米倉秀人
    • Organizer
      金沢医科大学医学会 第49回学術集会
    • Place of Presentation
      石川県内灘町 金沢医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Increased expression of Epac2 during in vitro tube formation in human microvascular endothelial cells.2012

    • Author(s)
      Yoshitake Y
    • Organizer
      22nd IUBMB & 37th FEBS Congress
    • Place of Presentation
      Sevilla, Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] 血管内皮細胞における可溶型Flt-1(可溶型VEGF受容体-1)mRNA選択的3'端プロセシング機構の解析.2012

    • Author(s)
      池田 崇之
    • Organizer
      第14回日本RNA学会年会
    • Place of Presentation
      仙台(川内萩ホール)
    • Related Report
      2012 Research-status Report
  • [Presentation] Flt-1(VEGF受容体-1)mRNA選択的3'端プロセシング機構の解析.2012

    • Author(s)
      池田 崇之
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡(福岡国際会議場・マリンメッセ福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] 毛細血管内皮細胞のマトリゲル上での管腔形成過程ではEpac2の発現が上昇する.2012

    • Author(s)
      吉竹 佳の
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡(福岡国際会議場・マリンメッセ福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] 低酸素状態はmRNA選択的3'端プロセシングを介して微小血管内皮細胞の可溶型VEGF受容体(可溶型Flt-1)産生を制御する.

    • Author(s)
      池田 崇之
    • Organizer
      日本生化学会北陸支部第30回記念大会(招待講演)
    • Place of Presentation
      金沢(歌劇座)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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